93390-44-4Relevant academic research and scientific papers
Combined Photoredox/Enzymatic C?H Benzylic Hydroxylations
Betori, Rick C.,May, Catherine M.,Scheidt, Karl A.
supporting information, p. 16490 - 16494 (2019/11/03)
Chemical transformations that install heteroatoms into C?H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C?H oxyfunctionalization, or the one step conversion of a C?H bond to a C?O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C?H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.
Manganese-catalyzed ring-opening carbonylation of cyclobutanol derivatives
Meyer, Tim,Yin, Zhiping,Wu, Xiao-Feng
supporting information, p. 864 - 867 (2019/02/20)
Herein, we report a manganese-catalyzed ring-opening carbonylation of cyclobutanol derivatives through cyclic C–C bond cleavage. The reaction happens via a radical-mediated pathway to selectively generate 1,5-ketoesters. A variety of substrates with subst
Asymmetric iodolactonization utilizing chiral squaramides
Tungen, Jorn E.,Nolsoe, Jens M. J.,Hansen, Trond V.
supporting information, p. 5884 - 5887 (2013/02/23)
Asymmetric iodolactonization of γ- and δ-unsaturated carboxylic acids has been explored in the presence of six different chiral organocatalysts 5-8. The catalyst 6b was found to facilitate the cyclization of 5-arylhex-5-enoic acids 1 to the corresponding
Chemoselective addition of Grignard reagents to alkoxycarbonylalkyl-N-imidazolium-N-methyl amides: Synthesis of 4-oxo and homologous esters
De Las Heras, Maria A.,Vaquero, Juan J.,Garcia-Navio, Jose L.,Alvarez-Builla, Julio
, p. 1817 - 1820 (2007/10/03)
A method for the synthesis of 4-oxo and homologous esters is achieved by metalation of alkoxycarbonylalkyl-N-imidazolium-N-methyl amides with 1 equiv of LDA followed by highly chemoselective addition of 1 equiv of a Grignard reagent.
A general and straightforward approach to α,ω-ketoesters
Babudri, Francesco,Fiandanese, Vito,Marchese, Giuseppe,Punzi, Angela
, p. 13513 - 13520 (2007/10/03)
Chemoselective cross-coupling reactions of monoesters of dicarboxylic acid chlorides with organocopper reagents derived from Grignard reagents, cuprous bromide, and lithium bromide, provide a simple and straightforward method for synthesizing a variety of ketoesters.
Preparation and Reactivities of (η3-1- and 2-Trimethylsiloxyallyl)Fe(CO2)NO Complexes. Intermediates Functioning as Equivalents of β- and α-Acyl Carbocations and Acyl Carbanions
Itoh, Keiji,Nakanishi, Saburo,Otsuji, Yoshio
, p. 2965 - 2977 (2007/10/02)
(η3-1- and 2-Trimethylsiloxyallyl)Fe(CO)2NO complexes were prepared by the reaction of the corresponding siloxyallylic halides with Bu4N.These complexes reacted with both of carbon nucleophiles and carbon electrophiles preferentially at the less hindered sites of the allylic ligands.In these reactions, (η3-1-trimethylsiloxyallyl)Fe(CO)2NO complexes served as synthetically equivalent synthons for both of β-acyl carbocations and β-acyl carbanions and (η3-2-trimethylsiloxyallyl)Fe(CO)2NO complexes as both of α-acyl carbocations and α-acyl carbanions.The stereochemical courses of the reactions are described.
Aspects of Tautomerism. Part 15. Investigations on Oxo-participation in δ-Oxocarboxylic Acid Chlorides during their Formation and Alcoholysis
Shashidhar, M. Srikantaiah,Bhatt, M. Vivekananda
, p. 355 - 358 (2007/10/02)
Oxalyl chloride converts ring-substituted 4-benzoylbutyric acids into a mixture of normal and pseudoacid chlorides by two independent and competing pathways.Pseudoacid chlorides are formed by a concerted 2?+2?+2? pathway.I
