934558-32-4Relevant academic research and scientific papers
4,4,6-Trimethyl-1,3,2-dioxaborinane: A practical reagent for palladium-catalyzed borylation of aryl halides
Murata, Miki,Oda, Takeshi,Watanabe, Shinji,Masuda, Yuzuru
, p. 351 - 354 (2007)
The palladium-catalyzed borylation of aryl iodides with 4,4,6-trimethyl-1,3,2-dioxaborinane is described. The mild reaction conditions employed allow for aryl iodides with a wide variety of functional groups to be tolerated. The products of this borylation were coupled with aryl halides to give biaryls in good yields. Georg Thieme Verlag Stuttgart.
Efficient borylation of reactive aryl halides with MPBH (4,4,6-trimethyl-1,3,2-dioxaborinane)
Praveenganesh, Nageswaran,Demory, Emilien,Gamon, Christine,Blandin, Véronique,Chavant, Pierre Y.
experimental part, p. 2403 - 2406 (2010/11/18)
The combination of 4,4,6-trimethyl-1,3,2-dioxaborinane, a particularly stable and inexpensive borylation reagent, and Buchwalds palladium catalyst provides a simple, fast, cost-effective borylation of electron-rich, reactive iodides, bromides, and triflates to produce stable, easily purified boronic esters. Georg Thieme Verlag Stuttgart New York.
Improved preparation of 4,6,6-trimethyl-1,3,2-dioxaborinane and its use in a simple [PdCl2(TPP)2]-catalyzed borylation of aryl bromides and iodides
PraveenGanesh, Nageswaran,Chavant, Pierre Yves
experimental part, p. 4690 - 4696 (2009/05/27)
We describe a convenient preparation of 4,6,6-trimethyl-1,3,2-dioxaborinane (MethylPentaneDiolBorane, MPBH) and demonstrate that it is an excellent reagent for the [PdCl2(PPh3)2]-catalyzed borylation of aryl bromides and iodides. The corresponding boronic esters undergo rapid Suzuki coupling reactions in the presence of cesium fluoride. Thus, MPBH is an excellent alternative to pinacolborane for Pd-catalyzed borylation and cross-coupling reactions. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
