934612-57-4Relevant academic research and scientific papers
Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands
Da Ressurreica o, Ana Sofia M.,Vidu, Anamaria,Civera, Monica,Belvisi, Laura,Potenza, Donatella,Manzoni, Leonardo,Ongeri, Sandrine,Gennari, Cesare,Piarulli, Umberto
supporting information; experimental part, p. 12184 - 12188 (2011/12/16)
A perfect fit: The nanomolar affinity of a diketopiperazine-derived cyclic RGD-peptidomimetic for the integrin αvβ 3 receptor can be attributed to its high structural pre-organization. The transdiketopiperazine scaffold induces an extended RGD disposition permitting all important interactions with the extracellular domain of the αvβ 3 integrin. The metal ion in the metaliondependent adhesion site region is represented by a magenta sphere.
Synthesis and biological evaluation of new conformationally biased integrin ligands based on a tetrahydroazoninone scaffold
Banfi, Luca,Basso, Andrea,Damonte, Gianluca,Pellegrini, Federico De,Galatini, Andrea,Guanti, Giuseppe,Monfardini, Ilaria,Riva, Renata,Scapolla, Carlo
, p. 1341 - 1345 (2008/02/04)
The synthesis of new conformationally biased cyclic pentapeptides, incorporating the RGD sequence, and built around a tetrahydroazoninone scaffold, is reported. They exhibit interesting activity towards integrin αVβ3 and a remarkable
