93483-71-7

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-N-(TERT-BUTYL)BENZAMIDE is used as a building block in organic synthesis for the development of pharmaceuticals. Its unique structure allows it to be a key component in the creation of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-AMINO-N-(TERT-BUTYL)BENZAMIDE is utilized as a precursor in the synthesis of agrochemicals, contributing to the development of new pesticides or other agricultural chemicals that can enhance crop protection and yield.
Used in Materials Science:
4-AMINO-N-(TERT-BUTYL)BENZAMIDE is employed in materials science for the synthesis of novel materials with specific properties. Its versatility in chemical reactions allows for the creation of materials with tailored characteristics for various applications.
Used in Antimicrobial Applications:
4-AMINO-N-(TERT-BUTYL)BENZAMIDE has been studied for its potential antimicrobial properties, making it a candidate for use as an antimicrobial agent in various settings, including medical and industrial applications, to combat microbial infections.
Used in Anticancer Research:
4-AMINO-N-(TERT-BUTYL)BENZAMIDE is also being investigated for its potential anticancer properties, with the aim of developing new therapeutic agents that could target and treat cancer cells effectively.
Overall, 4-AMINO-N-(TERT-BUTYL)BENZAMIDE's diverse potential applications highlight its importance as a chemical intermediate in multiple industries, underscoring the need for further research and development to fully harness its capabilities.

Upstream product

• 42498-30-6 N-tert-butyl-4-nitrobenzamide 
• 122-04-3 4-nitro-benzoyl chloride 
• 98-88-4 benzoyl chloride 
• 75-64-9 tert-butylamine 
• 62-23-7 4-nitro-benzoic acid 
• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 540-88-5 acetic acid tert-butyl ester 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 95005-17-7 2-(4-tert.-Butylcarbamoyl-phenylcarbamoyl)-2-(4-chlor-phenoxy)-propan 
• 205492-91-7 4-[(4,6-dichloro-1,3,5-triazine-2-yl)amino]-N-(1,1-dimethylethyl)benzamide 
• 1417547-04-6 N-(4-(tert-butylcarbamoyl)phenylcarbamoyl)-2,6-difluorobenzamide 
• 608523-51-9 6-[4-(tert-Butylcarbamoyl)phenylazo]-pyridoxal-5-phosphate 

Relevant academic research and scientific papers

VASCULAR ADHESION PROTEIN-1 (VAP-1) MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule Vascular Adhesion Protein- 1 (VAP-1) modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Preparation method of N-tert-butyl-4-aminobenzamide

The invention discloses a preparation method of N-tert-butyl-4-aminobenzamide. The preparation method of the N-tert-butyl-4-aminobenzamide comprises the steps that a condensation reaction is carried out on p-nitrobenzoyl chloride and tert-butylamine to ob

Synthesis and antitumor activity of novel phenylhydrazonopyrazolone derivatives and molecular dynamics simulations

SHP2 is a new promising target for anti-cancer drug discovery. A series of novel phenylhydrazonopyrazolone derivatives was synthesized by a more convenient method, and their chemical structures were characterized by various spectroscopic methods. The inhibitory effects of these compounds on SHP2 enzyme and SHP2-dependent cancer cell H1975 were evaluated. The compound 11f with IC50 value of 3.38?μmol/L exhibited more potent antitumor activity against H1975 cell than GS-493 (IC50 = 20.92?μmol/L). Molecular dynamics simulation of compound 11f displayed a possible mode of interaction between this compound and SHP2 enzyme.

Substituent effects in aminocarbonylation of para-substituted iodobenzenes

Iodobenzene derivatives possessing various substituents (amino, hydroxy, tert-butyl, methyl, isopropyl, phenyl, fluoro, chloro, methoxycarbonyl, acetyl, trifluoromethyl, nitro) in the para position were aminocarbonylated using tert-butylamine and n-butylamine as N-nucleophiles. A palladium(0) catalyst formed in situ from palladium(II) acetate and triphenylphosphine was used. Carboxamide and ketocarboxamide type compounds were formed via single and double carbon monoxide insertion, respectively. While 4-substituents with negative Hammett constants (σp) decrease reactivity of the substrates, the iodoaromatics possessing electron-withdrawing group (characterized by positive Hammett constants (σp)) in the 4-position have shown high reactivity. Highly active catalysts were obtained in the presence of xantphos accompanied by the chemoselective formation of the corresponding carboxamides. The difference in reactivity of iodoarene and bromoarene functionalities enabled the synthesis of bromo-substituted compounds suitable for further functionalization.

Design, synthesis, and insecticidal evaluation of new benzoylureas containing amide and sulfonate groups based on the sulfonylurea receptor protein binding site for diflubenzuron and glibenclamide

On the basis of the sulfonylurea receptor (SUR) protein binding site for diflubenzuron and glibenclamide, 15 new benzoylphenylureas containing amide and sulfonate groups were designed and synthesized. Their structures were characterized by 1H n

An efficient and scalable ritter reaction for the synthesis of tert-butyl amides

A scalable procedure for the conversion of nitriles to N-tert-butyl amides via the Ritter reaction was optimized employing tert-butyl acetate and acetic acid. The reaction has a broad scope for aromatic, alkyl, and α,β-unsaturated nitriles.

Photostable sunscreen compositions comprising cinnamate ester UV-B filters and s-triazine compounds

Photostable sunscreen compositions containing at least one cinnamic acid ester UV-B filter and at least one particular s-triazine compound have improved effectiveness with respect to UV-B radiation.

Photostable sunscreen compositions comprising dibenzoylmethane compound UV-A filters and s-triazine compounds

Photostable sunscreen compositions containing at least one dibenzoylmethane compound UV-A screening agent and at least one particular s-triazine compound have improved effectiveness with respect to UV-A radiation.

Photostable sunscreen compositions comprising cinnamic acid ester UV-B filters, dibenzoylmethane UV-A filters and s-triazine compounds

Photostable sunscreen compositions containing at least one cinnamic acid ester UV-B screening agent, at least one dibenzoylmethane compound UV-A screening agent and at least one particular s-triazine compound have improved effectiveness with respect to UV

Compositions containing an UV-B filter of the cinnamic acid ester type, a UV-A filter of the dibenzoylmethane type and a derivative of s-triazine; process of photostabilisation

Composition (A) comprising, in a cosmetic vehicle, at least one Uv filter system that comprises at least one each of: cinnamate ester-type Uv-B filter (A1); dibenzoylmethane-type Uv-A filter (A2) and specific tri-phenylamino-s-triazine compounds (I). Composition (A) comprising, in a cosmetic vehicle, at least one Uv filter system that comprises at least one each of: cinnamate ester-type Uv-B filter (A1); dibenzoylmethane-type Uv-A filter (A2) and specific tri-phenylamino-s-triazine compounds of formula (I). each X : O or NR 6; each R a-(CHR 4) n-(CHR 5) m-CR 1R 2R 3; R 1and R 21-8C linear or branched alkyl or together form a 5-8C ring, optionally substituted by 1-3 1-4C alkyl; R 3-R 5each : H or 1-4C alkyl; n and m : 0 or 1, but when n =1 and R 4= H, then m = 0 and R 3is not H, and when R 1and R 2complete a ring, then n+m is not 2; R 6H or 1-8C alkyl; R b= 1-20C linear or branched alkyl, optionally unsaturated, 5-12C cycloalkyl (optionally substituted by 1-3 1-4C alkyl), -(CH 2CHR 7O) qR 8or -CH 2CHOH-CH 2OR 8; R 7H or Me; R 8H or 1-8C alkyl; q : 1-20; COXR bis ortho, meta or para to the amino group; R c1-20C linear or branched alkyl, optionally unsaturated, hydroxy, or 1-20C alkoxy, linear or branched; p : 0-2. [Image].