93554-98-4

Basic information

• Product Name: 3-Methoxy-α-[(triMethylsilyl)oxy]-benzeneacetonitrile
• Synonyms: 3-Methoxy-α-[(triMethylsilyl)oxy]-benzeneacetonitrile
• CAS NO: 93554-98-4
• Molecular Formula: C₁₂H₁₇NO₂Si
• Molecular Weight: 235.35438
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 93554-98-4.mol
• Article Data: 41

Chemical Properties

• Boiling Point: 293.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.014±0.06 g/cm3(Predicted)
• Solubility: Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: 3-Methoxy-α-[(triMethylsilyl)oxy]-benzeneacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxy-α-[(triMethylsilyl)oxy]-benzeneacetonitrile(93554-98-4)
• EPA Substance Registry System: 3-Methoxy-α-[(triMethylsilyl)oxy]-benzeneacetonitrile(93554-98-4)

Safety Data

• Hazardous Substances Data: 93554-98-4(Hazardous Substances Data)

Usage

Uses

3-Methoxy-α-[(triMethylsilyl)oxy]-benzeneacetonitrile is a reactant used in the preparation of Methoxetamine (M226300) and D4 receptor ligands.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 151-50-8 potassium cyanide 
• 591-31-1 3-methoxy-benzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 94601-43-1 2-Hydroxy-2-(3-methoxy-phenyl)-acetimidic acid ethyl ester; hydrochloride 
• 258882-48-3 4-chloro-1-(3-methoxyphenyl)-1-butanone 
• 27382-17-8 2-acetoxy-2-(3-methoxyphenyl)acetonitrile 
• 53313-94-3 m-methoxymandelonitrile 
• 91481-20-8 DL-3-methoxyphenylglycine nitrile hydrochloride 
• 95392-04-4 α-Fluoro-α-(2-methylphenyl)acetonitrile 
• 27382-18-9 2-amino-1-(3-methoxyphenyl)ethanol 
• 32174-39-3 3-methoxymandelic acid 
• 34904-93-3 2-Hydroxy-2-(3-methoxyphenyl)-1-phenylethanone 
• 54845-40-8 methyl 2-hydroxy-2-(3-methoxyphenyl)acetate 
• 10049-65-7 (R)-(+)-2-hydroxy-2-(3-methoxyphenyl)acetonitrile 
• 10049-65-7 (S)-(-)-2-hydroxy-2-(3-methoxyphenyl)acetonitrile 
• 1424280-49-8 C₂₇H₄₄O₅Si 

Relevant articles and documents

Role of metal center and coordination environment in M-(Z)-N-((E)-pyridin-2-ylmethylene)isonicotinohydrazonate (M = LaIII, ZnII, CdII or HgII) catalyzed cyanosilylation of aldehydes

A series of known metal complexes, [LaL2(NO3)(H2O)2]·5H2O (1), [Zn(μ-L)(NO3)(H2O)]n (2), {[Cd2(μ-HL)(μ-L)(NO3)3(H2O)]·Hsub

Organo-catalyzed Michael addition of 2-fluoro-2-arylacetonitriles

An efficient synthesis of a variety of 2-arylacetonitriles containing a fluorinated stereogenic center through organo-catalyzed Michael addition reaction of 2-fluoro-2-arylacetonitriles has been developed. This protocol uses a cheap organocatalyst (DBU) and has a broad substrate scope: α, β-unsaturated ketones, esters, nitriles and sulfones were all successfully reacted. Importantly, water proved to be a good solvent for this reaction.

Zirconium-based MOF catalyst with double active sites and preparation method and application thereof

The invention discloses a zirconium-based MOF catalyst loaded with double active sites as well as a preparation method and an application of the zirconium-based MOF catalyst. The method comprises thefollowing steps: adding zirconium salt and an organic ligand into an organic solvent, taking organic acid as a regulator, and carrying out self-assembly reaction to obtain a metal organic framework; adding salicylaldehyde for aldehyde amine condensation to obtain chelating coordination sites, adding palladium salt, and performing coordination through an impregnation method; reducing the obtained MOF in hydrogen to obtain an MOF loaded with Pd nanoparticles; reacting MOF and zinc salt in an organic solvent, and obtaining the catalyst. The Pd-Zn-coated UiO-68-NH2-CH3 catalyst synthesized by thepreparation method disclosed by the invention has efficient catalytic activity in a tandem alcohol oxidation/aldehyde cyanosilylation reaction. According to the catalyst, a metal organic framework UiO-68-NH2-CH3 is constructed, Pd nanoparticles and Zn are loaded by taking the metal organic framework UiO-68-NH2-CH3 as a carrier, the loading capacity of the Pd nanoparticles is 4-8wt%, and the loading capacity of the Zn is 3-5wt%.