93554-98-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Methoxy-α-[(triMethylsilyl)oxy]-benzeneacetonitrile is used as a reactant for the preparation of Methoxetamine (M226300), a dissociative anesthetic and analgesic drug. It plays a crucial role in the synthesis process, enabling the production of 3-Methoxy-α-[(triMethylsilyl)oxy]-benzeneacetonitrile with potential therapeutic applications.
Additionally, 3-Methoxy-α-[(triMethylsilyl)oxy]-benzeneacetonitrile is used as a reactant in the synthesis of D4 receptor ligands. These ligands are significant in the development of drugs targeting the D4 receptor, which is implicated in various neurological and psychiatric disorders. 3-Methoxy-α-[(triMethylsilyl)oxy]-benzeneacetonitrile's reactivity and structural features make it a valuable component in the creation of these ligands, contributing to advancements in medicinal chemistry and drug discovery.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 151-50-8 potassium cyanide 
• 591-31-1 3-methoxy-benzaldehyde 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 94601-43-1 2-Hydroxy-2-(3-methoxy-phenyl)-acetimidic acid ethyl ester; hydrochloride 
• 53313-94-3 m-methoxymandelonitrile 
• 258882-48-3 4-chloro-1-(3-methoxyphenyl)-1-butanone 
• 100947-28-2 5-(3-Methoxy-phenyl)-oxazolidine-2,4-dione 
• 108772-78-7 4-(3-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 91578-93-7 N-benzyl-1-(3-methoxyphenyl)-2-aminoethanol 
• 1424280-49-8 C₂₇H₄₄O₅Si 
• 10049-65-7 (R)-(+)-2-hydroxy-2-(3-methoxyphenyl)acetonitrile 
• 10049-65-7 (S)-(-)-2-hydroxy-2-(3-methoxyphenyl)acetonitrile 
• 91481-20-8 DL-3-methoxyphenylglycine nitrile hydrochloride 
• 95392-04-4 α-Fluoro-α-(2-methylphenyl)acetonitrile 
• 27382-18-9 2-amino-1-(3-methoxyphenyl)ethanol 

Relevant academic research and scientific papers

Role of metal center and coordination environment in M-(Z)-N-((E)-pyridin-2-ylmethylene)isonicotinohydrazonate (M = LaIII, ZnII, CdII or HgII) catalyzed cyanosilylation of aldehydes

A series of known metal complexes, [LaL2(NO3)(H2O)2]·5H2O (1), [Zn(μ-L)(NO3)(H2O)]n (2), {[Cd2(μ-HL)(μ-L)(NO3)3(H2O)]·Hsub

Silyl Cyanopalladate-Catalyzed Friedel-Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives

3-Aryloxindole derivatives were synthesized through a Friedel-Crafts-type cyclization. The reaction was catalyzed by a trimethylsilyl tricyanopalladate complex generated in situ from trimethylsilyl cyanide and Pd(OAc) 2. Wide varieties of diethyl phosphates derived from N -arylmandelamides were converted almost quantitatively into oxindoles. When N, N -dibenzylamide was used instead of an anilide substrate, a benzo-fused δ-lactam was obtained. An oxindole product was subjected to substitution reactions to afford 3,3-diaryloxindoles with two different aryl groups.

Organo-catalyzed Michael addition of 2-fluoro-2-arylacetonitriles

An efficient synthesis of a variety of 2-arylacetonitriles containing a fluorinated stereogenic center through organo-catalyzed Michael addition reaction of 2-fluoro-2-arylacetonitriles has been developed. This protocol uses a cheap organocatalyst (DBU) and has a broad substrate scope: α, β-unsaturated ketones, esters, nitriles and sulfones were all successfully reacted. Importantly, water proved to be a good solvent for this reaction.

A novel 3D terbium metal-organic framework as a heterogeneous Lewis acid catalyst for the cyanosilylation of aldehyde

A novel 3D lanthanide(iii) metal-organic framework (MOF) (namely Tb-MOF), was synthesized by self-assembly from Tb(iii) ion nitrate and the rigid organic ligand H2sbdc (H2sbdc = 5,5-dioxo-5H-dibenzo[b,d]thiophene-3,7-dicarboxylic acid), and could work as

Zirconium-based MOF catalyst with double active sites and preparation method and application thereof

The invention discloses a zirconium-based MOF catalyst loaded with double active sites as well as a preparation method and an application of the zirconium-based MOF catalyst. The method comprises thefollowing steps: adding zirconium salt and an organic ligand into an organic solvent, taking organic acid as a regulator, and carrying out self-assembly reaction to obtain a metal organic framework; adding salicylaldehyde for aldehyde amine condensation to obtain chelating coordination sites, adding palladium salt, and performing coordination through an impregnation method; reducing the obtained MOF in hydrogen to obtain an MOF loaded with Pd nanoparticles; reacting MOF and zinc salt in an organic solvent, and obtaining the catalyst. The Pd-Zn-coated UiO-68-NH2-CH3 catalyst synthesized by thepreparation method disclosed by the invention has efficient catalytic activity in a tandem alcohol oxidation/aldehyde cyanosilylation reaction. According to the catalyst, a metal organic framework UiO-68-NH2-CH3 is constructed, Pd nanoparticles and Zn are loaded by taking the metal organic framework UiO-68-NH2-CH3 as a carrier, the loading capacity of the Pd nanoparticles is 4-8wt%, and the loading capacity of the Zn is 3-5wt%.

Manganese-organic framework assembled by 5-((4′-(tetrazol-5″-yl)benzyl)oxy)isophthalic acid: A solvent-free catalyst for the formation of carbon–carbon bond

A new three-dimensional manganese-based metal–organic framework Mn4L2(HL)(H2O)5, (1), based on semi-rigid 5-((4′-(tetrazol-5′’-yl)benzyl)oxy)isophthalic acid ligand (H3L) have been prepared and charac

A Zn(ii)-organic cage with semirigid ligand for solvent-free cyanosilylation and inhibitory effect on ovarian cancer cell migration and invasion ability via regulating mi-RNA16 expression

[Zn6(L)4(DMF)2(H2O)4](1,4-Dioxane)2(DMF)10(H2O)4 (1, L = 4,4′,4″-(benzene-1,3,5-triyltris(oxy))tribenzoate), the metal-organic cage, was produced via Zn(NO3)2·6H2O reacting with the H3L ligand in the mixed solvent of DMF and water. The heterogeneous catal

Solvent-free cyanosilylation of aromatic and heteroaryl aldehydes catalyzed by a cationic iron N-heterocyclic carbene complex at ambient temperature under UV irradiation

The cyanosilylation of aromatic aldehydes and heteroaryl aldehydes with trimethylsilyl cyanide (TMSCN) is efficiently catalyzed by an iron complex of the type {[3-isopropyl-1-(1R-phenylethyl)imidazol-2-ylidene]Fe(CO)2}I (3) in presence of UV li

N-Heterocyclic Germylene and Stannylene Catalyzed Cyanosilylation and Hydroboration of Aldehydes

Recent years have witnessed a significant growth in the area of low-valent main-group compounds due to their potential to activate small molecules. However, there is a paucity of examples of low-valent main-group compounds being used as single-site cataly

Novel primary amide-based cationic metal complexes: Green synthesis, crystal structures, Hirshfeld surface analysis and solvent-free cyanosilylation reaction

A new symmetrical and flexible primary amide functionalized ligand, 2,2′-(ethane-1,2-diylbis((pyridin-2-ylmethyl)azanediyl))diacetamide (2-BPEG), has been synthesized and structurally characterized. Using this multidentate ligand, four novel metal complex