258882-48-3Relevant academic research and scientific papers
Pyrazole-based sulfonamide and sulfamides as potent inhibitors of mammalian 15-lipoxygenase
Ngu, Khehyong,Weinstein, David S.,Liu, Wen,Langevine, Charles,Combs, Donald W.,Zhuang, Shaobin,Chen, Xing,Madsen, Cort S.,Harper, Timothy W.,Ahmad, Saleem,Robl, Jeffrey A.
scheme or table, p. 4141 - 4145 (2011/08/06)
A series of inhibitors of mammalian 15-lipoxygenase (15-LO) based on a 3,4,5-tri-substituted pyrazole scaffold is described. Replacement of a sulfonamide functionality in the lead series with a sulfamide group resulted in improved physicochemical properties generating analogs with enhanced inhibition in cell-based and whole blood assays.
SUBSTITUTED BUTYROPHENONE DERIVATIVES
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Page/Page column 14; 15, (2008/06/13)
The present invention relates to a central nervous system-acting substituted butyrophenones. These compounds are useful in antipsychotic medications for psychosis, including schizophrenia, but especially for L-DOPA-induced psychosis, while having low or n
A structure-affinity relationship study on derivatives of N-[2-[4-(4- chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D4 receptor ligand
Perrone, Roberto,Berardi, Francesco,Colabufo, Nicola A.,Leopoldo, Marcello,Tortorella, Vincenzo
, p. 270 - 277 (2007/10/03)
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide (1), a high-affinity and selective dopamine D4 receptor ligand, was chosen as a lead, and structural modifications were done on its amide bond and on its alkyl chain linking the b
1-(2-methoxyphenyl)-4-alkylpiperazines: Effect of the N-4 substitutent on the affinity and selectivity for dopamine D4 receptor
Perrone, Roberto,Berardi, Francesco,Colabufo, Nicola A.,Leopoldo, Marcello,Tortorella, Vincenzo
, p. 1327 - 1330 (2007/10/03)
Binding data on dopaminergic D2 and D6 and adrenergic eel receptors of nine methoxyphenyl)piperazine derivatives are reported. The benzamide derivative 11 and ketone 12 displayed the highest affinity for human cloned D4 re
