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Upstream product

• 1092806-31-9 Cbz-Val-(7-Bromo-Trp)-OH 
• 72635-81-5 ((benzyloxy)carbonyl)-L-valyl-L-serine 
• 3496-11-5 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate 
• 577-19-5 2-nitrophenyl bromide 
• 51417-51-7 7-bromo-1H-indole 
• 640281-37-4 (S,RS)-methyl 2-(2-benzyloxycarbonylamino-3-methylbutanoylamino)-3-(7-bromoindol-3-yl)propanoate 

Relevant academic research and scientific papers

DIAZONAMIDE ANALOGS WITH IMPROVED SOLUBILITY

Diazonamide A analogs, and the salts, esters and conjugates thereof, having improved aqueous solubility are provided. Also provided are pharmaceutical compositions, and methods for preparing and using such compounds and compositions for the treatment of proliferative diseases.

DIAZONAMIDE ANALOGS

Novel diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.

INDOLINE ANTI-CANCER AGENTS

Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.

A Concise and Flexible Total Synthesis of (-)-Diazonamide A

The remarkable action of an IIII species on a tripeptide containing acyclic tyrosine/ tryptophan is the key step in a total synthesis of (-)-diazonamide A. The completed preparation of this new antimitotic is concise, multiply convergent, and a