640281-37-4

Upstream product

• 72635-81-5 ((benzyloxy)carbonyl)-L-valyl-L-serine 
• 3496-11-5 2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate 
• 577-19-5 2-nitrophenyl bromide 
• 51417-51-7 7-bromo-1H-indole 
• 1092806-31-9 Cbz-Val-(7-Bromo-Trp)-OH 
• 77-76-9 2,2-dimethoxy-propane 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 

Downstream Products

• 1092806-31-9 Cbz-Val-(7-Bromo-Trp)-OH 
• 936017-37-7 methyl 2-((S)-1-((S)-2-(benzyloxycarbonylamino)-3-(4-hydroxyphenyl)propanamido)-2-methylpropyl)-5-(7-bromo-1H-indol-3-yl)oxazole-4-carboxylate 

Relevant academic research and scientific papers

Diazonamide studies. A direct synthesis of the indole bis-oxazole fragment from tri- and tetra-peptides using biomimetic oxidative cyclizations

The oxidation of several readily prepared tryptophan containing tri- and tetrapeptides with DDQ results in a biomimetic cyclization and direct formation of the indole bis-oxazole fragment of diazonamide A, establishing that such a transformation is a viab

INDOLINE ANTI-CANCER AGENTS

Indoline compounds having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.

DIAZONAMIDE ANALOGS

Novel diazonamide analogs having anti-mitotic activity, useful for the treatment of cancer and other proliferative disorders are provided.

A Concise and Flexible Total Synthesis of (-)-Diazonamide A

The remarkable action of an IIII species on a tripeptide containing acyclic tyrosine/ tryptophan is the key step in a total synthesis of (-)-diazonamide A. The completed preparation of this new antimitotic is concise, multiply convergent, and a