75437-11-5

Upstream product

• 57427-78-8 (4Z)-4-(4-methoxybenzylidene)-2-phenyl-oxazolin-5-one 
• 495-69-2 Hippuric Acid 
• 67-56-1 methanol 
• 5429-22-1 4-(4-methoxybenzylidene)-2-phenyl-5(4H)-oxazolone 
• 123-11-5 4-methoxy-benzaldehyde 
• 186581-53-3 diazomethane 
• 100-66-3 methoxybenzene 

Downstream Products

• 105962-37-6 methyl Z-2-benzamido-3-p-methoxyphenyl-2-butanoate 
• 32058-04-1 4-(4-methoxy-phenyl)-1⁽²⁾H-pyrazole-3-carboxylic acid methyl ester 
• 111016-45-6 4-(4-methoxyphenyl)-1H-pyrazole 
• 110356-26-8 4-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid 
• 93634-70-9 (R)-4-methoxy-N-benzoyl-phenylalanine-methylester 
• 18217-57-7 (S)-4-methoxy-N-benzoyl-phenylalanine-methylester 
• 54797-23-8 trans-N-[2-(4-Methoxy-phenyl)-vinyl]-benzamide 
• 16242-09-4 4-benzoylamino-5-(4-methoxy-phenyl)-pyrazolidin-3-one 
• 187836-07-3 methyl (N-benzoyl)-4'-methoxyphenylalaninate 

Relevant academic research and scientific papers

Ni(ii)-Catalyzed vinylic C-H functionalization of 2-acetamido-3-arylacrylates to access isotetronic acids

A ligand-free Ni(ii)-catalyzed cascade annulation reaction for the synthesis of 4-aryl-substituted isotetronic acids from 2-acetamido-3-arylacrylatesviavinylic C-H functionalization is reported. The reaction proceeds through heteroatom guided electrophilic insertion of nickel to the vinylic double bond followed by annulation with dibromomethane. This unconventional route features cascade steps, sole product formation, multiple functional group tolerance, low cost of catalysts and reagents, and readily available starting materials. Using this method, various aryl-substituted isotetronic acids have been synthesized which are biologically relevant. The annulation of 2-acetamido-3-arylacrylates has also been assessed with 1,2-dichloroethane, which resulted in the rearranged annulated products of 5-methyl substituted isotetronic acids.

Reactivity of unsaturated 5(4H)-oxazolones with Hg(II) acetate: Synthesis of methyl N-benzoylamino-3-arylacrylates

An efficient and high-yield procedure to prepare methyl N-benzoylamino-3-arylacrylates from unsaturated (Z)-2-aryl-4-arylidene-5-(4H)- oxazolones and Hg(OAc)2 in methanol is described herein. The observed reactivity of mercury(II) acetate here

One-pot process to Z-α-benzoylamino-acrylic acid methyl esters via potassium phosphate-catalyzed Erlenmeyer reaction

A practical and efficient two reaction sequence one-pot process for the synthesis of Z-α-benzoylamino-acrylic acid methyl esters was developed. The process involves a potassium phosphate-catalyzed Erlenmeyer reaction of aromatic aldehydes with hippuric acid followed by an oxazolone ring-opening methanolysis. This process afforded a good overall yield and an excellent product quality via a simple workup.

An usual behaviour of ethers in presence of azlactones under ultrasound irradiation to give esters

The phenomenon of ester formation from ethers and azlactones under sonolysis has been observed.

A new methodology for the synthesis of N-acylaminocinnamates

A new synthesis of biologically active N-protected amino acids (2) and amides (4) from 4-ylidene-5(4H)-oxazolones (1) is described.

SYNTHESIS OF N-(E)-(4-METHOXYSTYRYL)BENZAMIDE (ALATAMIDE)

The synthesis of N-(E)-(4-methoxystyryl)benzamide (alatamide) (1), an alkamide constituent of P. alatum (Rutaceae) has been achieved through the decarboxylation of the enamido-ester (9).