936847-61-9

Upstream product

• 462-06-6 fluorobenzene 
• 103-80-0 phenylacetyl chloride 
• 936847-59-5 methyl 4-(4-methyl-3-oxopentanamido)benzoate 
• 88675-31-4 2-bromo-1-(4-fluorophenyl)-2-phenylethan-1-one 
• 62148-67-8 2-chloro-1-(4-fluorophenyl)-2-phenylethan-1-one 
• 150-13-0 4-amino-benzoic acid 
• 619-45-4 4-methoxycarbonyl aniline 
• 347-84-2 1-(4-fluorophenyl)-2-phenylethanone 
• 936847-63-1 (Z)-methyl 4-{[2-benzylidene-4-methyl-3-oxopentanoyl]amino}benzoate 
• 936847-62-0 (E)-methyl 4-{[2-benzylidene-4-methyl-3-oxopentanoyl]amino}benzoate 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 936756-74-0 tert-butyl 2-[(4R,6R)-6-{2-[2-(4-fluorophenyl)-4-{[4-(hydroxymethyl)phenyl]carbamoyl}-3-phenyl-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl]acetate 

Relevant academic research and scientific papers

METHOD OF PREPARING(3R,5R)-7-(2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4-((4-HYDROXYMETHYLPHENYLAMINO)CARBONYL)-PYRROL-1-YL)-3,5-DIHYDROXY-HEPTANOIC ACID HEMI CALCIUM SALT, AND METHOD OF PREPARING INTERMEDIATES USED THEREIN

The present invention provides a method for preparing (3R,5R)-7-(2-(4-flurophenyl)-5-isopropyl-3-phenyl-4-((4-hydroxymethylphenylamino)carbonyl)-pyrrole-1-yl)-3,5-dihydroxy heptanoic acid hemicalcium salt. The preparation method of the present invention is performed in a convergent synthesis manner in which main structural moieties of a (3R,5R)-7-(2-(4-flurophenyl)-5-isopropyl-3-phenyl-4-((4-hydroxymethylphenylamino)carbonyl)-pyrrole-1-yl)-3,5-dihydroxy heptanoic acid hemicalcium salt are independently synthesized, and then coupled. Accordingly, related substances can be easily controlled and preparing time can be reduced, thus improving the productivity of a compound, and the yield of a final compound can also be increased.

PROCESS FOR (3R, 5R)-7-[2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4- [(4-HYDROXY METHYL PHENYL AMINO) CARBONYL]-PYRROL-1-YL]-3, 5-DIHYDROXY-HEPTANOIC ACID HEMI CALCIUM SALT

The present invention relates to processes for the manufacture of (3 R, 5R)-7-[2-(4- fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]- pyrrol-l-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt.