93690-87-0Relevant academic research and scientific papers
Enhancement of enantioselectivity in the optical resolution of primary alcohols with modified cyclodextrin colyophilized lipase
Shioji, Kosei,Kurauchi, Yoshimitsu,Terada, Keiko,Kodera, Yasushi,Okuma, Kentaro
, p. 2163 - 2170 (2008/02/07)
Colyophilization of lipase was carried out with immobilized β-cyclodextrins (β-CyD) bearing methyl, acetyl, benzoyl, and nicotinoyl substituents. The colyophilizates enhanced stereoselectivity in the acylation of several alcohols. The enantioselectivity in the acylation of ethyl-1-hydroxymethyl-phenylphosphine oxide using colyophilized lipase with nicotinoyl-β-CyD increased approximately threefold (from E=34 to E=113). The amphiphilic character of modified CyDs has been found to influence the enhancement of enantioselectivity. Copyright Taylor & Francis Group, LLC.
