937701-36-5Relevant academic research and scientific papers
A versatile approach to β-amyloid fibril-binding compounds exploiting the shirakawa/hayashi protocol for trans-alkene synthesis
Huynh, Tri H. V.,Mantel, Mette Louise H.,Mikkelsen, Katrine,Lindhardt, Anders T.,Nielsen, Niels ChR.,Otzen, Daniel,Skrydstrup, Troels
supporting information; experimental part, p. 999 - 1002 (2009/07/18)
Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of β-amyloid fibril binding compounds possessing a styrylbenzene motif such as FSB, an FSB dimer
New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques
Chandra, Rajesh,Oya, Shunichi,Kung, Mei-Ping,Hou, Catherine,Jin, Lee-Way,Kung, Hank F.
, p. 2415 - 2423 (2008/02/05)
A series of 18F fluoropegylated diphenylacetylenes as probes for binding to Aβ plaques were successfully prepared. These relatively rigid acetylenes, 12a, 12b, 14a, and 14b, displayed high binding affinities in postmortem AD brain homogenates (
