93780-03-1

Basic information

• Product Name: (S)-2-BENZYLPENT-4-ENOIC ACID
• Synonyms: (S)-2-BENZYLPENT-4-ENOIC ACID
• CAS NO: 93780-03-1
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 0
• Mol File: 93780-03-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-BENZYLPENT-4-ENOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-BENZYLPENT-4-ENOIC ACID(93780-03-1)
• EPA Substance Registry System: (S)-2-BENZYLPENT-4-ENOIC ACID(93780-03-1)

Safety Data

• Hazardous Substances Data: 93780-03-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(S)-2-BENZYLPENT-4-ENOIC ACID is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for versatile reactions and the creation of a wide range of products.
Used in Pharmaceutical Industry:
(S)-2-BENZYLPENT-4-ENOIC ACID is used as a building block in the pharmaceutical industry for the development of new drugs. Its specific properties and structure make it a valuable component in the synthesis of potential therapeutic agents.
Used in Chemical Research and Development:
(S)-2-BENZYLPENT-4-ENOIC ACID is used as a research molecule to study its properties and potential applications. Its stereochemistry and structure make it an important subject for understanding the behavior of similar compounds and their interactions with other molecules.

Upstream product

• 15814-45-6 allyl 3-phenylpropionate 
• 93684-30-1 3-Allyl-4-isopropyl-2-[2-phenyl-eth-(Z)-ylidene]-oxazolidine 
• 7154-69-0 2-benzylpent-4-enamide 
• 205373-70-2 (2'R,4R)-N-(2'-allyl-3'phenylpropanoyl)-4-benzyl-1,3-oxazolidin-2-one 
• 100-39-0 benzyl bromide 
• 556-56-9 allyl iodid 
• 704879-67-4 benzyl N-[(4S,5R)-4-benzyl-3-(3-phenylpropionyl)-1,3-oxazolidin-2-one-5-carbonyl]piperidine-4-carboxylate 
• 501-52-0 3-Phenylpropionic acid 
• 18620-18-3 2-benzyl-4-pentenenitrile 
• 851968-91-7 benzyl N-[(4S,5S)-4-benzyl-3-(3-phenylpropionyl)-1,3-oxazolidin-2-one-5-carbonyl]piperidine-4-carboxylate 
• 1035797-56-8 C₁₄H₁₈O₃ 
• 704879-66-3 benzyl N-[(4S,5R)-4-benzyl-1,3-oxazolidin-2-one-5-carbonyl]piperidine-4-carboxylate 
• 704879-65-2 1-((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyryl)-piperidine-4-carboxylic acid benzyl ester 
• 136159-65-4 (S)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one 

Downstream Products

• 1012314-16-7 (3S,5R)-3-benzyl-5-(iodomethyl)dihydrofuran-2(3H)-one 

Relevant articles and documents

Dual Activation of Unsaturated Amides with Schwartz's Reagent: A Diastereoselective Access to Cyclopentanols and N,O-Dimethylcyclopentylhydroxylamines.

The diastereoselective access to cyclopentanols and N,O-dimethylcyclopentylhydroxylamines from 4-pentenoic acid-derived Weinreb amides is described. Based on the concomitant generation of both the nucleophilic and the electrophilic poles by hydrozirconati

Convergent Evolution of Diastereomeric Mixtures of 5-Methoxy-pentylzirconocenes toward Trans-1,2-substituted Cyclopentanes

The access to 1,2- and 1,1,2-substituted trans cyclopentanes via a sequential hydrozirconation/TMSOTf-mediated cyclization applied to 5-methoxypent-1-enes is presented. Involving a transient carbocation, the reaction was shown to be diastereo-convergent. Possibly performed in a nonracemic version, the reaction proved compatible with a range of functional groups affording a large panel of cyclopentanes.

Soluble polymer supported 2-imidazolidinone chiral auxiliary and method for manufacturing the same

The present invention relates to a chiral auxiliary agent and a manufacturing method thereof and, more specifically, to a 2-imidazolidinone chiral auxiliary agent supported onto a polymer soluble in an organic solvent and a manufacturing method thereof. The chiral auxiliary agent in the present invention shows effects of being easy to separate reaction products and the chiral auxiliary agent after a termination of a reaction while fulfilling an economic efficacy of chiral auxiliary molecules by being supported onto the polymer soluble in the organic solvent.COPYRIGHT KIPO 2015

Solid phase asymmetric alkylation reactions using 2-imidazolidinone chiral auxiliary

A novel solid supported 2-imidazolidinone chiral auxiliary was prepared from O-benzyl-l-tyrosine and Wang resin. Asymmetric alkylation reactions in the solid phase proceeded with excellent stereoselectivities, which were even higher than those observed in the conventional solution phase method.

Fluorine-directed diastereoselective iodocyclizations

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Remarkable electronic and steric effects in the nitrile biotransformations for the preparation of enantiopure functionalized carboxylic acids and amides: Implication for an unsaturated carbon-carbon bond binding domain of the amidase

(Chemical Equation Presented) Biotransformations of various functionalized racemic nitriles catalyzed by Rhodococcus erythropolis AJ270, a nitrile hydratase/amidase-containing microbial whole-cell catalyst, were studied. While the nitrile hydratase exhibi

Design and synthesis of a new polymer-supported Evans-type oxazolidinone: An efficient chiral auxiliary in the solid-ph ase asymmetric alkylation reactions

Wang resin-supported Evans' chiral auxiliary (23) was designed based on a novel polymer-anchoring strategy, which utilizes the 5-position of the oxazolidinone ring, and its new synthetic route applicable to multi-gram preparation in just a day was developed. Solid-phase Evans' asymmetric alkylation on 23-derived N-acylimide resin and following lithium hydroperoxide-mediated chemoselective hydrolysis afforded the corresponding α-branched carboxylic acids in desired high stereoselectivities (up to 97% ee) and moderate to good overall yield (up to 70%, for 3 steps), which were comparable to those of the conventional solution-phase methods. Furthermore, recovery and recycling of the polymer-supported chiral auxiliary were successfully achieved without decreasing the stereoselectivity of the product. Therefore, this is the first successful example that the solid-phase Evans' asymmetric enolate-alkylation was efficiently performed on the solid-support, and it is concluded that the connection to the solid-support via the 5-position of the oxazolidinone ring is an ideal strategy in the solid-phase Evans' chiral auxiliary.

A new polymer-supported Evans-type chiral auxiliary derived from α-hydroxy-β-amino acid, phenylnorstatine: Synthesis and application in solid-phase asymmetric alkylation reactions

Based on a new anchoring strategy, a polymer-supported chiral oxazolidinone was prepared starting from (2R,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid (phenylnorstatine, Pns) and Wang resin. Solid-phase asymmetric alkylation on this resin proceeded in high diastereoselectivity comparable to that of conventional solution-phase model experiments. This study suggests that anchoring through the 5-position of oxazolidinone is highly suited to achieving diastereoselective alkylation reactions on solid-support.

Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space

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Asymmetric synthesis of intermediates for retroviral protease inhibitor compounds

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