93782-07-1

Basic information

• Product Name: 2-amino-N-methyl-2-phenylacetamide
• Synonyms: 2-amino-N-methyl-2-phenylacetamide;6-Bromo-1-cyclopentyl-1H,2H,3H-imidazo[4,5-b]pyridin-2-one
• CAS NO: 93782-07-1
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 282.13648
• EINECS: 938-966-9
• Mol File: 93782-07-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-amino-N-methyl-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-N-methyl-2-phenylacetamide(93782-07-1)
• EPA Substance Registry System: 2-amino-N-methyl-2-phenylacetamide(93782-07-1)

Safety Data

• Hazardous Substances Data: 93782-07-1(Hazardous Substances Data)

Usage

Physical Form

White crystalline powder

Application

Used in pharmaceutical synthesis

Functional Groups

Amino Group (-NH2)
Methyl Group (-CH3)
Phenyl Group (-C6H5)

Potential Uses

Intermediate in organic synthesis
Building block for complex compounds

Safety Precautions

Proper handling and storage required

Hazards

Not specified, but general chemical safety guidelines apply.

Upstream product

• 53059-79-3 2-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-N-methyl-2-phenyl-acetamide 
• 6097-58-1 ethyl 2-phenyl-2-aminoacetate 
• 74-89-5 methylamine 
• 15028-40-7 DL-2-phenylglycine methyl ester hydrochloride 
• 5840-78-8 4-phenyl-oxazolidine-2,5-dione 
• 2835-06-5 phenylglycin 
• 108-86-1 bromobenzene 
• 150884-50-7 benzaldehyde N-boc imine 
• 875-74-1 (R)-phenylglycine 

Downstream Products

• 78139-29-4 2-methyl-4-phenyl-1,2,5-thiadiazol-3-one 
• 93782-08-2 N-acetyl-D,L-phenylglycine methylamide 
• 126179-91-7 (R)-N-hexa-4,5-dienyl-N-methyl-1-phenyldimethylene diamine 
• 126179-90-6 (R)-N-methyl-2-(N'-hexa-4,5-dienylamino)-2-phenylacetamide 
• 126179-96-2 N-<(R)-α-N-methyl(aminomethyl)benzyl>-(S)-2-vinylpyrrolidine 
• 126180-08-3 N-<(R)-α-N-methyl(aminomethyl)benzyl>-(R)-2-vinylpyrrolidine 
• 126179-95-1 (R)-N-methyl(phenyl)<(S)-2-vinylpyrrolidin-1-yl>acetamide 
• 126180-07-2 (R)-N-methyl(phenyl)<(R)-2-vinylpyrrolidin-1-yl>acetamide 

Relevant articles and documents

Efficient synthesis of α-amino secondary amides by direct aminocarbonylation of N-Boc-imines using carbamoylsilane as an amide source

A novel and practical procedure for the preparation of α-amino secondary amides by the aminocarbonylation of N-Boc-imines using carbamoylsilanes bearing methoxymethyl group as secondary amides source is presented herein. The protocol tolerates N-Boc-imines bearing different groups, including aryl, double bond conjugated aryl, heteroaryl and aliphatic groups. The reactions provide good to excellent yields of the products under mild and catalysts-free conditions. The electronic property and the steric hindrance of substituent on the N-Boc-imines affect the reaction.

A Concise Enantiodivergent Synthesis of Equol

Equol, a nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein, has been synthesized as both enantioenriched forms based on MacMillan's α-Arylation of carbonyl compound mediated by amino acid derived indazolidinones and copper precatalysts. The natural form of (S)-equol and its enantiomer (R)-equol have been synthesized in 8 steps from 2,4-dimethoxybenzaldehyde with good enantiomeric purity (90% ee and 90% ee, respectively).

The asymmetric reduction of imidazolinones with trichlorosilane

It is shown how imidazolinones are reduced by trichlorosilane in a highly enantioselective fashion when treated with a novel Lewis base organocatalyst that is based on a 2,2′-bispyrrolidine core. Under mild reaction conditions and with low catalyst loading the hydrosilylation reaction provides a broad range of chiral imidazolidinones with various structural motifs including sterically demanding substituents, alkyls and aryls.

Asymmetric synthesis of 4-aryl-1,2,5-thiadiazolidin-3-one 1,1-dioxides via Pd-catalyzed hydrogenation of cyclic ketimines

An efficient access to optically active sulfahydantoins, 4-aryl-1,2,5-thiadiazolidin-3-one 1,1-dioxides, was developed through palladium-catalyzed asymmetric hydrogenation of the corresponding cyclic N-sulfonylketimines with up to 98% ee.

INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND THE PRODUCTION METHODS THEREOF

Intermediate compounds for the preparation of mirtazapine and obtention methods thereof. A method is described for obtaining (±)-3-phenyl-1-methylpiperazine, an important intermediate for obtaining mirtazapine, which is based on imposing a cyclation reaction, in the presence of a reducing agent, on new compounds of general formula (I) in which Z is a leaving group capable of undergoing a nucleophylic displacement. A method is also described for obtaining the new compounds of formula (I).

Effect of structural modification of the hydrantoin ring on anticonvulsant activity

Selectively substituted hydantoins (15 examples), 4-hydroxy-2-imidazolidinones (13 examples), 2-imidazolones (10 examples), 2-imidazolidinones (four examples), vicinal diamines (two examples), and simple amino acid derivatives (four examples) have been pr