93819-35-3

Upstream product

• 3058-39-7 4-iodobenzonitrile 
• 5216-36-4 4,4'-ethynediyl-di-benzonitrile 
• 75-05-8 acetonitrile 
• 3032-92-6 4-cyanophenylacetylene 
• 75867-40-2 4-[2-(trimethylsilyl)ethynyl]benzonitrile 
• 88407-66-3 2-methyl-4,5-di(4'nitrophenyl)-oxazole 
• 544-92-3 copper(I) cyanide 
• 92968-29-1 4,4'-(2-methyl-oxazole-4,5-diyl)-bis-aniline 

Downstream Products

• 58764-21-9 4,4'-(2-methyl-oxazole-4,5-diyl)-bis-benzoic acid dimethyl ester 
• 94960-14-2 4,4'-(2-methyl-oxazole-4,5-diyl)-bis-benzamide 

Relevant academic research and scientific papers

Iodonium Cation-Pool Electrolysis for the Three-Component Synthesis of 1,3-Oxazoles

The synthesis of 1,3-oxazoles from symmetrical and unsymmetrical alkynes was realized by an iodonium cation-pool electrolysis of I2 in acetonitrile with a well-defined water content. Mechanistic investigations suggest that the alkyne reacts with the acetonitrile-stabilized I+ ions, followed by a Ritter-type reaction of the solvent to a nitrilium ion, which is then attacked by water. The ring closure to the 1,3-oxazoles released molecular iodine, which was visible by the naked eye. Also, some unsymmetrical internal alkynes were tested and a regioselective formation of a single isomer was determined by two-dimensional NMR experiments.