93820-00-9Relevant academic research and scientific papers
Chemo-enzymatic synthesis of oligoglycerol derivatives
Singh, Abhishek K.,Nguyen, Remi,Galy, Nicolas,Haag, Rainer,Sharma, Sunil K.,Len, Christophe
, (2016)
A cleaner and greener method has been developed and used to synthesize 14 different functionalized oligomer derivatives of glycerol in moderate 29%-39% yields over three steps. After successive regioselective enzymatic acylation of the primary hydroxyl groups, etherification or esterification of the secondary hydroxyl groups and chemoselective enzymatic saponification, the target compounds can efficiently be used as versatile building blocks in organic and supramolecular chemistry.
Oligo-glycerol based non-ionic amphiphilic nanocarriers for lipase mediated controlled drug release
Aarti,Achazi, Katharina,Haag, Rainer,Mittal, Ayushi,Nie, Chuanxiong,Parmanand,Sharma, Sunil K.,Singh, Abhishek K.
, p. 37555 - 37563 (2020/10/28)
A new class of non-ionic amphiphiles is synthesized using a diaryl derivative of diglycerol as a central core and functionalizing it with long alkyl chains (C-12/C-15) and monomethoxy PEG moiety (Mn: 350/550) by following a chemo-enzymatic approach. The aggregation behavior of the amphiphiles in aqueous medium is studied by using dynamic light scattering (DLS) and fluorescence spectroscopy, whereas the size and morphology of the aggregates are studied by transmission electron microscopy (TEM). A hydrophobic dye, Nile red and a hydrophobic drug, nimodipine, are used to demonstrate the nano-carrier capability of these non-ionic amphiphilic systems and the results are compared with amphiphilic analogues obtained from the triaryl derivatives of triglycerol. Thein vitrocontrolled release of the encapsulated dye is successfully carried out in the presence of immobilizedCandida antarcticalipase (Novozym 435). Furthermore, cytotoxicity data is also collected which suggests that the amphiphiles are suitable for biomedical applications.
