93913-62-3

Upstream product

• 100-39-0 benzyl bromide 
• 143949-25-1 (R,E)-ethyl 2,6-dimethyl-8-oxooct-2-enoate 
• 2385-77-5 (R)-Citronellal 
• 84051-33-2 (2S,3R,6S)-6-((R)-1-(benzyloxy)prop-2-yl)-3-methyl-2-((E)-3-(trimethylsilyl)but-2-en-1-yl)cyclohexanone 
• 84051-32-1 (2S,5R)-2-((R)-1-(benzyloxy)propan-2-yl)-5-methylcyclohexanone 
• 84051-31-0 (1R,5R)-2-(2-Benzyloxy-1-methyl-ethyl)-5-methyl-cyclohexanol 
• 13834-07-6 (1R,5R)-2-(2-Hydroxy-1-methyl-ethyl)-5-methyl-cyclohexanol 
• 100-44-7 benzyl chloride 
• 84051-31-0 <1R>-5(R)-methyl-2(S)-<1(R)-methyl-2-(phenylmethoxy)ethyl>cyclohexanol 
• 13834-07-6 (1R,3R,4S,8R)-9-hydroxy-p-menthol 
• 43209-86-5 3-trimethylsilyl-3-buten-2-one 

Downstream Products

• 87322-21-2 (R)-2-{(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-cyclohexyl}-propionic acid methyl ester 
• 106623-24-9 (R)-2-{(1R,2S,3S,4R)-2-Formyl-4-methyl-3-[2-(2-methyl-[1,3]dithian-2-yl)-ethyl]-cyclohexyl}-propionic acid methyl ester 
• 87322-20-1 (R)-2-[(1S,3S,4R)-2-[1-Methoxy-meth-(Z)-ylidene]-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester 
• 93913-64-5 1α,10α-methyl-7β-<2'β-(1'-benzyloxy)-propyl>-decalone-4 
• 93913-66-7 1α-Δ³-4,10α-dimethyl-7β-<2'β-(1'-benzyloxy)-propyl>-decalin 
• 93913-65-6 1α-Δ⁴-4,10α-dimethyl-7β-<2'β-(1'-benzyloxy)-propyl>-decalin 
• 63968-64-9 arteannuin (Qinghaosu) 
• 103775-34-4 (R)-2-[(1R,2S,3S,4R)-2-Formyl-4-methyl-3-(3-oxo-butyl)-cyclohexyl]-propionic acid methyl ester 
• 85031-59-0 dihydroartemisinic acid 

Relevant academic research and scientific papers

A novel asymmetric total synthesis of (+)-artemisinin

A 12-step synthesis of the natural product (+)-Artemisinin, very active against malaria, is described. (-)-Isopulegol, which already contains two of the asymmetric centers of (+)-Artemisinin in the correct absolute configuration, was used as starting material.

Asymmetric synthesis of dihydroartemisinic acid through intramolecular Stetter reaction

A short and concise formal synthesis of enantiopure dihydroartemisinic acid from (R)-citronellal is described in this article. Intramolecular version of asymmetric Stetter reaction using Rovis aminoindane based NHC catalyst was explored to access the core

TOTAL SYNTHESIS OF ARTEANNUIN AND DEOXYARTEANNUIN

Arteannuin 1 is a new sesquiterpene lactone containing a peroxide linkage and is an antimalarial principle isolated from Artemisia annua L. .R(+)-Citronellal 5 as a starting material for the total synthesis was converted into 11R(-)-methyl dihydroarteannuinate 12 in 14 steps.The key intermediate 4 was obtained from compound 12 in 5 steps.The introduction of hydroperoxide in 4 by photooxidation followed by acid treatment gave 1.Hydroxylation of 4 with osmium tetraoxide afforded deoxyarteannuin 2.