A novel asymmetric total synthesis of (+)-artemisinin

Article abstract of DOI:10.1080/00397919608003621

A 12-step synthesis of the natural product (+)-Artemisinin, very active against malaria, is described. (-)-Isopulegol, which already contains two of the asymmetric centers of (+)-Artemisinin in the correct absolute configuration, was used as starting material.

Full text of DOI:10.1080/00397919608003621

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A Novel Asymmetric Total
Synthesis of (+)-Artemisinin
Mauricio Gomes Constantino a , Milton Beltrame
Jr. a , Gil Valdo José da Silva a & Julio Zukerman-
Schpector b
a Departamento de Quimica Faculdade de
Filosofia, Ciěncias e Letras de RibeirãTo Preto
Universidade de São Paulo, Av. Bandeirantes,
3900, CEP 14040–901, Ribeirão Preto-SP, Brazil
b Departamento de Quimica, Universidade
Federal de São Carlos Caixa, Postal 676, CEP
13565–905, São Carlos-SP, Brazil
Published online: 21 Aug 2006.
To cite this article: Mauricio Gomes Constantino , Milton Beltrame Jr. , Gil Valdo
José da Silva & Julio Zukerman-Schpector (1996): A Novel Asymmetric Total
Synthesis of (+)-Artemisinin, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 26:2, 321-329
To link to this article: http://dx.doi.org/10.1080/00397919608003621
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