94033-64-4

Usage

Chemical Properties

White solid

Upstream product

• 98-86-2 acetophenone 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 7063-99-2 ethyl 5-phenylisoxazole-3-carboxylate 
• 5932-30-9 ethyl 5-phenylpyrazole-3-carboxylate 
• 56426-35-8 3-phenylpyrazole-5-carboxylic acid methyl ester 
• 13599-12-7 ethyl 3-phenyl-1H-pyrazole-5-carboxylate 

Downstream Products

• 518987-38-7 5,6-Dimethyl-2-(4-phenyl-2H-pyrazol-3-yl)-1H-benzoimidazole 
• 366014-94-0 C₁₇H₁₅N₅OS 
• 366007-57-0 4-amino-5-(5-phenyl-2H-pyrazol-3-yl)-4H-[1,2,4]triazole-3-thiol 
• 366014-90-6 C₁₁H₁₁N₅OS 
• 1353877-16-3 N'-(6-methoxy-3-methylbenzofuran-2-carbonyl)-3-phenyl-1H-pyrazole-5-carbohydrazide 
• 1353877-22-1 2-(6-methoxy-3-methylbenzofuran-2-yl)-5-(3-phenyl-1H-pyrazol-5-yl)-1,3,4-oxadiazole 
• 1134-49-2 3-phenyl-1H-pyrazole-5-carboxylic acid 

Relevant academic research and scientific papers

Discovery of heterocyclic carbohydrazide derivatives as novel selective fatty acid amide hydrolase inhibitors: design, synthesis and anti-neuroinflammatory evaluation

Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat pain, inflammation, and other central nervous system disorders. Herein, a series of novel heterocyclic carbohydrazide derivatives were firstly designed by the classic scaffold-hopping strategy. Then, multi-steps synthesis and human FAAH enzyme inhibiting activity assays were conducted. Among them, compound 26 showed strong inhibition against human FAAH with IC50 of 2.8 μM. Corresponding docking studies revealed that the acyl hydrazide group of compound 26 well-occupied the acyl-chain binding pocket. It also exhibited high selectivity towards FAAH when comparing with CES2 and MAGL. Additionally, compound 26 effectively suppressed the LPS-induced neuroinflammation of microglial cells (BV2) via the reduction of interleukin-1β and tumor necrosis factor-α. Our results provided significative lead compounds for the further discovery of novel selective and safe FAAH inhibitors with potent anti-neuroinflammation activity.

Hydroxamic Acid-Based Histone Deacetylase (HDAC) inhibitors bearing a pyrazole scaffold and a cinnamoyl linker

Genetic abnormalities have been conventionally considered as hallmarks of cancer. However, recent studies have demonstrated that epigenetic mechanisms are also implicated in the insurgence and development of cancer. Patterns of the epigenetic component in

Coumarins nickel ion fluorescent probe and preparation method thereof, preparation method of crystal and application

The invention provides a coumarins nickel ion fluorescent probe and a preparation method thereof, a preparation method of a crystal and application. The structure of a coumarins compound is as follows: a formula is shown in the description. Compared with

Synthesis of new bis-pyrazole linked hydrazides and their in vitro evaluation as antimicrobial and anti-biofilm agents: A mechanistic role on ergosterol biosynthesis inhibition in Candida albicans

Literature reports suggest that pyrazoles and hydrazides are potential antimicrobial pharmocophores. Considering this fact, a series of nineteen conjugates containing hybrids of bis-pyrazole scaffolds joined through a hydrazide linker were synthesized and

Pyrazole-oxadiazole conjugates: Synthesis, antiproliferative activity and inhibition of tubulin polymerization

A number of pyrazole-oxadiazole conjugates were synthesized and evaluated for their ability to function as antiproliferative agents on various human cancer cell lines. These conjugates are comprised of pyrazole and oxadiazole scaffolds closely attached to each other without any spacer as two structural classes. The Type I class has a trimethoxy substituent and the type II class has a 3,4-(methylenedioxy) substituent on their A rings. Among these conjugates, 11a, 11d and 11f manifest potent cytotoxicity with IC50values ranging from 1.5 μM to 11.2 μM and inhibit tubulin polymerization with IC50values of 1.3 μM, 3.9 μM and 2.4 μM respectively. The cell cycle assay showed that treatment with these conjugates results in accumulation of cells in the G2/M phase and disrupts the microtubule network. Elucidation of zebrafish embryos revealed that the conjugates cause developmental defects. Molecular docking simulations determined the binding modes of these potent conjugates at the colchicine site of tubulin.

Synthesis, X-ray crystal structure and optical properties of novel 5-(3-aryl-1H-pyrazol-5-yl)-2-(6-methoxy-3-methylbenzofuran-2-yl)-1,3, 4-oxadiazole

A series of novel 5-(3-aryl-1H-pyrazol-5-yl)-2-(6-methoxy-3- methylbenzofuran-2-yl)-1,3,4-oxadiazole derivatives has been synthesized from 6-methoxy-3-methylbenzofuran-2-carboxylic acid and ethyl 3-aryl-1H-pyrazole-5- carboxylate. The structures of compou