94033-64-4

Basic information

• Product Name: 3-PHENYL-1H-PYRAZOLE-5-CARBOHYDRAZIDE
• Synonyms: AKOS BBS-00004529;3-PHENYL-1H-PYRAZOLE-5-CARBOHYDRAZIDE
• CAS NO: 94033-64-4
• Molecular Formula: C₁₀H₁₀N₄O
• Molecular Weight: 202.21
• Mol File: 94033-64-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-PHENYL-1H-PYRAZOLE-5-CARBOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYL-1H-PYRAZOLE-5-CARBOHYDRAZIDE(94033-64-4)
• EPA Substance Registry System: 3-PHENYL-1H-PYRAZOLE-5-CARBOHYDRAZIDE(94033-64-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 94033-64-4(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Upstream product

• 98-86-2 acetophenone 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 7063-99-2 ethyl 5-phenylisoxazole-3-carboxylate 
• 5932-30-9 ethyl 5-phenylpyrazole-3-carboxylate 
• 56426-35-8 3-phenylpyrazole-5-carboxylic acid methyl ester 
• 13599-12-7 ethyl 3-phenyl-1H-pyrazole-5-carboxylate 

Downstream Products

• 518987-38-7 5,6-Dimethyl-2-(4-phenyl-2H-pyrazol-3-yl)-1H-benzoimidazole 
• 366007-57-0 4-amino-5-(5-phenyl-2H-pyrazol-3-yl)-4H-[1,2,4]triazole-3-thiol 
• 366014-90-6 C₁₁H₁₁N₅OS 
• 1353877-16-3 N'-(6-methoxy-3-methylbenzofuran-2-carbonyl)-3-phenyl-1H-pyrazole-5-carbohydrazide 
• 1353877-22-1 2-(6-methoxy-3-methylbenzofuran-2-yl)-5-(3-phenyl-1H-pyrazol-5-yl)-1,3,4-oxadiazole 
• 1134-49-2 3-phenyl-1H-pyrazole-5-carboxylic acid 
• 366014-98-4 5-(5-phenyl-2H-pyrazol-3-yl)-4H-[1,2,4]triazole-3-thiol 

Relevant articles and documents

Discovery of heterocyclic carbohydrazide derivatives as novel selective fatty acid amide hydrolase inhibitors: design, synthesis and anti-neuroinflammatory evaluation

Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat pain, inflammation, and other central nervous system disorders. Herein, a series of novel heterocyclic carbohydrazide derivatives were firstly designed by the classic scaffold-hopping strategy. Then, multi-steps synthesis and human FAAH enzyme inhibiting activity assays were conducted. Among them, compound 26 showed strong inhibition against human FAAH with IC50 of 2.8 μM. Corresponding docking studies revealed that the acyl hydrazide group of compound 26 well-occupied the acyl-chain binding pocket. It also exhibited high selectivity towards FAAH when comparing with CES2 and MAGL. Additionally, compound 26 effectively suppressed the LPS-induced neuroinflammation of microglial cells (BV2) via the reduction of interleukin-1β and tumor necrosis factor-α. Our results provided significative lead compounds for the further discovery of novel selective and safe FAAH inhibitors with potent anti-neuroinflammation activity.

Coumarins nickel ion fluorescent probe and preparation method thereof, preparation method of crystal and application

The invention provides a coumarins nickel ion fluorescent probe and a preparation method thereof, a preparation method of a crystal and application. The structure of a coumarins compound is as follows: a formula is shown in the description. Compared with

Pyrazole-oxadiazole conjugates: Synthesis, antiproliferative activity and inhibition of tubulin polymerization

A number of pyrazole-oxadiazole conjugates were synthesized and evaluated for their ability to function as antiproliferative agents on various human cancer cell lines. These conjugates are comprised of pyrazole and oxadiazole scaffolds closely attached to each other without any spacer as two structural classes. The Type I class has a trimethoxy substituent and the type II class has a 3,4-(methylenedioxy) substituent on their A rings. Among these conjugates, 11a, 11d and 11f manifest potent cytotoxicity with IC50values ranging from 1.5 μM to 11.2 μM and inhibit tubulin polymerization with IC50values of 1.3 μM, 3.9 μM and 2.4 μM respectively. The cell cycle assay showed that treatment with these conjugates results in accumulation of cells in the G2/M phase and disrupts the microtubule network. Elucidation of zebrafish embryos revealed that the conjugates cause developmental defects. Molecular docking simulations determined the binding modes of these potent conjugates at the colchicine site of tubulin.