5932-30-9

Basic information

• Product Name: 5-PHENYL-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 5-PHENYL-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER;ethyl 5-phenyl-1H-pyrazole-3-carboxylate;1H-Pyrazole-3-carboxylic acid, 5-phenyl-, ethyl ester;5-Phenyl-4H-pyrazole-3-carboxylic acid ethyl ester;3-Ethoxycarbonyl-5-phenylpyrazole;3(5)-phenyl-5(3)-ethoxycarbonylpyrazole;ethyl 5-phenyl-2H-pyrazole-3-carboxylate;Ethyl 5-phenylpyrazole-3-carboxylate
• CAS NO: 5932-30-9
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.24
• Mol File: 5932-30-9.mol
• Article Data: 26

Chemical Properties

• Melting Point: 140-141.5℃
• Boiling Point: 427.9°C at 760 mmHg
• Flash Point: 212.6°C
• Appearance: /
• Density: 1.196±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.58E-07mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-PHENYL-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PHENYL-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(5932-30-9)
• EPA Substance Registry System: 5-PHENYL-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(5932-30-9)

Safety Data

• Hazardous Substances Data: 5932-30-9(Hazardous Substances Data)

Usage

General Description

5-Phenyl-pyrazole-3-carboxylic acid ethyl ester is a chemical compound with the molecular formula C12H12N2O2. It is a pyrazole derivative with a phenyl group attached to the pyrazole ring. 5-PHENYL-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER is commonly used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active compounds. It has been found to exhibit antimicrobial, antitumor, and anti-inflammatory properties, making it a valuable intermediate in the development of new drugs and agrochemicals. Additionally, 5-phenyl-pyrazole-3-carboxylic acid ethyl ester has also been studied for its potential use in the development of new materials and as a tool in chemical research.

InChI:InChI=1/C12H12N2O2/c1-2-16-12(15)11-8-10(13-14-11)9-6-4-3-5-7-9/h3-8H,2H2,1H3,(H,13,14)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 536-74-3 phenylacetylene 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 5071-61-4 5-phenyl-1H-pyrazole-3-carboxylic acid 
• 141-52-6 sodium ethanolate 
• 94274-67-6 tert-Butylammonium- 
• 126580-12-9 (E)-ethyl 2-diazo-4-phenylbut-3-enoate 
• 75-64-9 tert-butylamine 
• 25445-76-5 acetophenone N-ethoxycarbonylhydrazone 
• 95-92-1 oxalic acid diethyl ester 
• 98-86-2 acetophenone 
• 122-78-1 phenylacetaldehyde 
• 126580-09-4 ethyl 2-diazo-3-hydroxy-4-phenylbutyrate 
• 14441-90-8 5-phenyl-3-isoxazolecarboxylic acid 

Downstream Products

• 179057-19-3 (5-phenyl-1H-pyrazol-3-yl)methanol 
• 952191-72-9 ethyl 1-[(4-methylphenyl)sulfonyl]-5-phenyl-1H-pyrazole-3-carboxylate 
• 1105634-84-1 ethyl 1-isobutyl-5-phenyl-1H-pyrazole-3-carboxylate 
• 94033-64-4 5-phenyl-1H-pyrazole-3-carbohydrazide 
• 10199-51-6 1-methyl-5-phenyl-1H-prazole-3-carboxylic acid ethyl ester 
• 869901-13-3 3-chloromethyl-1-methyl-5-phenyl-1H-pyrazole 
• 124344-98-5 (1-methyl-5-phenyl-1H-pyrazol-3-yl)methanol 
• 10250-63-2 1-methyl-3-phenyl-1H-prazole-5-carboxylic acid ethyl ester 

Relevant articles and documents

Generation of Diazomethyl Radicals by Hydrogen Atom Abstraction and Their Cycloaddition with Alkenes

A general catalytic methodology for the synthesis of pyrazolines from α-diazo compounds and conjugated alkenes is reported. The direct hydrogen atom transfer (HAT) process of α-diazo compounds promoted by the tert-butylperoxy radical generates electrophilic diazomethyl radicals, thereby reversing the reactivity of the carbon atom attached with the diazo group. The regiocontrolled addition of diazomethyl radicals to carbon-carbon double bonds followed by intramolecular ring closure on the terminal diazo nitrogen and tautomerization affords a diverse set of pyrazolines in good yields with excellent regioselectivity. This strategy overcomes the limitations of electron-deficient alkenes in traditional dipolar [3+2]-cycloaddition of α-diazo compounds with alkenes. Furthermore, the straightforward formation of the diazomethyl radicals provides umpolung reactivity, thus opening new opportunities for the versatile transformations of diazo compounds.

PYRIMIDINONE-CONTAINING COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

Disclosed is a pyrimidinone-containing compound represented by formula I, a preparation method thereof, a pharmaceutical composition, and an application thereof. The pyrimidinone-containing compound of the present disclosure can be used as HIV-1 inhibitor

Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment

Membrane-bound pyrophosphatases (mPPases) regulate energy homeostasis in pathogenic protozoan parasites and lack human homologues, which makes them promising targets in e.g. malaria. Yet only few nonphosphorus inhibitors have been reported so far. Here, w