94048-14-3

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 80646-87-3 6,5'-cyclo-1-(5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)uracil 
• 57901-60-7 5-bromo-2',3'-O-isopropylidene-5'-O-(p-toluenesulfonyl)uridine 
• 81356-82-3 2',3'-O-isopropylidene-5-chlorouridine 
• 94048-46-1 5'-O-p-toluenesulfonyl-2',3'-O-isopropylidene-5-chlorouridine 
• 80646-85-1 5'-bromo-5'-deoxy-2',3'-O-isopropylidene-5-chlorouridine 
• 94048-48-3 5'-deoxy-5'-iodo-2',3'-O-isopropylidene-5-bromouridine 
• 94048-47-2 5'-deoxy-5'-iodo-2',3'-O-isopropylidene-5-chlorouridine 
• 94048-49-4 6,5'-cyclo-5'-deoxy-2'3'-O-isopropylidene-5-bromo-5,6-dihydrouridine 
• 80646-86-2 6,5'-cyclo-5'-deoxy-2'3'-O-isopropylidene-5(R),6(R)-dihydro-5-chlorouridine 

Relevant academic research and scientific papers

Synthesis of 6,5'-cyclo-5'-deoxyuridines by radical cyclization (nucleosides and nucleotides. L)

6,5'-Cyclo-5'-deoxyuridine, a fixed anti form of uridine, was synthetized by a radical cyclization of 5'-bromo(or iodo)-5'-deoxy-2',3'-O-isopropylidene-5-chloro(or bromo)-uridine and tri-n-butyltin hydride followed by dehydrohalogenation and deacetonation. The 5-bromo and 4-thio derivatives of the cyclouridine were also prepared and were converted to the 2',3'-cyclic phosphates. These nucleotides were hydrolyzed by pancreatic ribonuclease. The result showed that the enzyme recognizes the pyrimidine nucleotides in the anti form. 6,5'-Cyclo-5'-deoxycytidine was also synthesized by two routes.