94048-47-2 Usage
Uses
Used in Organic Synthesis:
5'-DEOXY-5'-IODO-2',3'-O-ISOPROPYLIDENE-5-CHLOROURIDINE is used as a synthetic intermediate for the preparation of various organic compounds. Its reactivity and functional groups enable it to participate in a wide range of chemical reactions, making it a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5'-DEOXY-5'-IODO-2',3'-O-ISOPROPYLIDENE-5-CHLOROURIDINE is used as a key intermediate in the synthesis of nucleoside analogs, which are important antiviral and anticancer agents. Its unique structure allows for the development of novel therapeutic agents with improved potency and selectivity.
Used in Agrochemical Industry:
5'-DEOXY-5'-IODO-2',3'-O-ISOPROPYLIDENE-5-CHLOROURIDINE is also utilized in the agrochemical industry as a precursor for the synthesis of nucleoside-based insecticides and fungicides. Its incorporation into these compounds can lead to enhanced pest control and crop protection.
Used in Research and Development:
In the field of research and development, 5'-DEOXY-5'-IODO-2',3'-O-ISOPROPYLIDENE-5-CHLOROURIDINE serves as a valuable tool for studying the structure-activity relationships of nucleoside analogs. Its unique properties allow researchers to probe the mechanisms of action and develop new strategies for drug design and optimization.
Check Digit Verification of cas no
The CAS Registry Mumber 94048-47-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,4,0,4 and 8 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 94048-47:
(7*9)+(6*4)+(5*0)+(4*4)+(3*8)+(2*4)+(1*7)=142
142 % 10 = 2
So 94048-47-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H14ClIN2O5/c1-12(2)20-7-6(3-14)19-10(8(7)21-12)16-4-5(13)9(17)15-11(16)18/h4,6-8,10H,3H2,1-2H3,(H,15,17,18)/t6-,7+,8?,10-/m1/s1
94048-47-2Relevant academic research and scientific papers
An efficient synthetic approach to 6,5′-(S)- and 6,5′-(R)- cyclouridine
Theile, Christopher S.,McLaughlin, Larry W.
supporting information; experimental part, p. 5587 - 5589 (2012/07/17)
Here we present new routes for the efficient syntheses of 6,5′-(S)- and 6,5′-(R)-cyclouridine. The syntheses utilize readily accessible uridine as a starting material. This route to the R diastereomer is significantly more efficient than previous synthetic efforts, allowing us to obtain large amounts of pure material for future biological testing.
Synthesis of 6,5'-cyclo-5'-deoxyuridines by radical cyclization (nucleosides and nucleotides. L)
Ueda,Usui,Shuto,Inoue
, p. 3410 - 3416 (2007/10/02)
6,5'-Cyclo-5'-deoxyuridine, a fixed anti form of uridine, was synthetized by a radical cyclization of 5'-bromo(or iodo)-5'-deoxy-2',3'-O-isopropylidene-5-chloro(or bromo)-uridine and tri-n-butyltin hydride followed by dehydrohalogenation and deacetonation. The 5-bromo and 4-thio derivatives of the cyclouridine were also prepared and were converted to the 2',3'-cyclic phosphates. These nucleotides were hydrolyzed by pancreatic ribonuclease. The result showed that the enzyme recognizes the pyrimidine nucleotides in the anti form. 6,5'-Cyclo-5'-deoxycytidine was also synthesized by two routes.
