81356-82-3

Usage

Uses

Used in Organic Synthesis:
5-Chloro-2',3'-O-isopropylidene-D-uridine is used as a synthetic intermediate for the preparation of various organic compounds. Its unique structure allows for the development of new molecules with potential applications in various industries.

Upstream product

• 4105-38-8 Tri-O-acetyluridine 
• 58-96-8 uridine 
• 3370-68-1 2',3',5'-tri-O-acetyl-5-chlorouridine 
• 2880-89-9 5-chlorouridine 
• 67-64-1 acetone 
• 362-43-6 2',3'-O-isopropylideneuridine 

Downstream Products

• 87817-97-8 5-Chloro-1-((3aR,4R,6R,6aR)-6-methoxymethoxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-6-phenylsulfanyl-1H-pyrimidine-2,4-dione 
• 87818-07-3 5-Chloro-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-phenylsulfanyl-1H-pyrimidine-2,4-dione 
• 94048-46-1 5'-O-p-toluenesulfonyl-2',3'-O-isopropylidene-5-chlorouridine 
• 94048-14-3 6,5'-cyclo-5'-deoxy-2',3'-O-isopropylidenecytidine mesitylenesulfonate 
• 94048-47-2 5'-deoxy-5'-iodo-2',3'-O-isopropylidene-5-chlorouridine 

Relevant academic research and scientific papers

An efficient synthetic approach to 6,5′-(S)- and 6,5′-(R)- cyclouridine

Here we present new routes for the efficient syntheses of 6,5′-(S)- and 6,5′-(R)-cyclouridine. The syntheses utilize readily accessible uridine as a starting material. This route to the R diastereomer is significantly more efficient than previous synthetic efforts, allowing us to obtain large amounts of pure material for future biological testing.

In-cell Indirect Electrochemical Halogenation of Pyrimidine Bases and their Nucleosides to 5-Haloderivatives

Reaction of anodically generated "halonium" species (LiX or Bu4NX, LiClO4, MeCN, Pt/Pt; I2, LiClO4, MeCN) with pyrimidine bases and their nucleosides leads to 5-halo compounds in good yields.