94052-40-1Relevant academic research and scientific papers
One-pot synthesis of 2,5-disubstituted pyrimidines from nitriles
Frutos, Rogelio P.,Wei, Xudong,Patel, Nitinchandra D.,Tampone, Thomas G.,Mulder, Jason A.,Busacca, Carl A.,Senanayake, Chris H.
, p. 5800 - 5803 (2013/07/25)
A practical, one-step process for the synthesis of 2,5-disubstituted pyrimidines is presented. The protocol proved to be general for the synthesis of a variety of pyrimidine-containing compounds bearing an assortment of functional groups.
NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7
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Page/Page column 54, (2009/10/17)
The present invention relates to imidazolone derivatives of formula (I) to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives, and methods of inhibiting protein kinase, and methods of treatment comprising administration of such derivatives.
A facile and versatile route to 2-substituted-4(3H)-quinazolinones and quinazolines
Connolly,Guiry
, p. 1707 - 1710 (2007/10/03)
A range of 2-aryl and 2-alkyl quinazolinones have been prepared in moderate to good yields from the reaction of anthranilic acid and the appropriately substituted imidate in a facile, mild, onepot procedure. Subsequent reaction with phosphorus oxychloride afforded the corresponding 4-chloro-2-substituted quinazolines, which are useful synthetic intermediates, in good to high yields. Product isolation was facilitated by the development of work up procedures for both reactions that did not include purification by column chromatography.
Synthesis of N-(α-Methoxyalkyl) Amides from Imidates
Lokensgard, Jerrold P.,Fischer, John W.,Bartz, William J.
, p. 5609 - 5611 (2007/10/02)
Two general routes from imidates to N-(α-methoxyalkyl) amides (e.g.,R'CONHCH(OCH3)R, 1) are reported.The first involves acylation of the imidate on nitrogen with an acyl chloride, followed by reduction with sodium borohydride.In the second, an aldehyde is converted, via its methyl acetal, to an α-chloro methyl ether, which is used to alkylate the imdate.Further treatment with pyridinium chloride in dry Me2SO yields 1.Thirteen examples are reported.
