94084-76-1

Basic information

• Product Name: 6-(benzyloxy)nicotinic acid
• Synonyms: 6-(benzyloxy)nicotinic acid
• CAS NO: 94084-76-1
• Molecular Formula: C12H11NO3
• Molecular Weight: 229
• Product Categories: Carboxylic Acids;Carboxylic Acids;Pyridines
• Mol File: 94084-76-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 400.3°C at 760 mmHg
• Flash Point: 195.9°C
• Appearance: /
• Density: 1.274g/cm³
• Vapor Pressure: 3.99E-07mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 6-(benzyloxy)nicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(benzyloxy)nicotinic acid(94084-76-1)
• EPA Substance Registry System: 6-(benzyloxy)nicotinic acid(94084-76-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 94084-76-1(Hazardous Substances Data)

Usage

General Description

6-(benzyloxy)nicotinic acid, also known as Benzyl 6-hydroxynicotinate, is a chemical compound that belongs to the class of organic compounds known as benzyloxypyridines. It is a derivative of nicotinic acid and is commonly used as a building block for the synthesis of various bioactive molecules and pharmaceutical drugs. 6-(benzyloxy)nicotinic acid acts as a valuable intermediate in the preparation of pharmaceuticals and agrochemicals and is also used as a precursor in the production of a wide variety of other chemical substances. Additionally, it possesses antioxidant and anti-inflammatory properties, making it potentially useful in the development of new therapeutic agents.

InChI:InChI=1/C13H11NO3/c15-13(16)11-6-7-12(14-8-11)17-9-10-4-2-1-3-5-10/h1-8H,9H2,(H,15,16)

Upstream product

• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 66171-50-4 methyl 6-hydroxynicotinate 
• 151028-49-8 methyl 6-(benzyloxy)nicotinate 
• 100-51-6 benzyl alcohol 
• 33252-28-7 6-chloronicotinonitrile 
• 83664-33-9 2-(benzyloxy)-5-bromopyridine 
• 124-38-9 carbon dioxide 
• 876516-71-1 6-(benzyloxy)nicotinonitrile 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 

Relevant articles and documents

First identification of boronic species as novel potential inhibitors of the Staphylococcus aureus NorA efflux pump

Overexpression of efflux pumps is an important mechanism of bacterial resistance that results in the extrusion of antimicrobial agents outside the bacterial cell. Inhibition of such pumps appears to be a promising strategy that could restore the potency of existing antibiotics. The NorA efflux pump of Staphylococcus aureus confers resistance to a wide range of unrelated substrates, such as hydrophilic fluoroquinolones, leading to a multidrug-resistance phenotype. In this work, approximately 150 heterocyclic boronic species were evaluated for their activity against susceptible and resistant strains of S. aureus. Twenty-four hit compounds, although inactive when tested alone, were found to potentiate ciprofloxacin activity by a 4-fold increase at concentrations ranging from 0.5 to 8 μg/mL against S. aureus 1199B, which overexpresses NorA. Boron-free analogues showed no biological activity, thus revealing that the boron atom is crucial for biological activity. This work describes the first reported efflux pump inhibitory activity of boronic acid derivatives.

PYRROLIDINYL AND PIPERIDINYL COMPOUNDS USEFUL AS NHE-1 INHIBITORS

Disclosed are compounds of formula (I) and compositions of the present invention which are inhibitors of the sodium proton exchanger isoform-1 (NHE-I). Also disclosed are methods of using and making the same.

Pyridine amido derivatives

Disclosed are pyridine amido derivatives of the formula wherein X, Y, and R1 to R6 are as defined herein. These compounds are selective MAO-B inhibitors and are useful in treating diseases such as, for example, Alzheimer's and senile dementia. Also disclosed are pharmaceutical compositions containing such compounds and a method of preparing such compounds.