94100-08-0

Upstream product

• 93-17-4 3,4-dimethoxyphenylacetonitrile 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 105278-82-8 5-chloro-3',4'-dimethoxy-2-(phthalimidoacetamido)benzophenone 
• 115765-00-9 8-chloro-6-(3,4-dimethoxyphenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 115764-98-2 8-chloro-6-(3,4-dimethoxyphenyl)-1-methyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 115103-03-2 7-chloro-5-(3,4-dimethoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione 
• 105278-81-7 7-chloro-5-(3,4-dimethoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one 
• 94100-07-9 2-amino-5-chloro-3',4'-dimethoxybenzophenone 

Relevant academic research and scientific papers

Mechanism of formation of 2,1-benzisoxazoles in reactions of nitroarenes with arylacetonitriles

Main regularities in reactions of arylacetonitriles with nitroarenes were discussed. The reaction mechanism has been suggested proceeding from the experimental data and the quantum chemical modeling of the limiting stage, the formation of the 2,1-benzisoxazole ring.

REACTIONS OF 4-CHLORO-1-NITROBENZENE WITH (3-CHLORO-4-METHOXYPHENYL)ACETONITRILE AND (3,4-DIMETHOXYPHENYL)ACETONITRILE; SYNTHESIS OF 8-CHLORO-1-METHYL (AND METHYLTHIOMETHYL)-6-(3,4-DISUBSTITUTED PHENYL)-4H-s-TRIAZOLO-1,4-BENZODIAZEPINES

Reactions of 4-chloro-1-nitrobenzene with (3-chloro-4-methoxyphenyl)acetonitrile and (3,4-dimethoxyphenyl)acetonitrile in methanolic potassium hydroxide gave the corresponding 3-aryl-5-chloro-2,1-benzisoxazoles Ia and Ib in good yields; compounds Va, Vb, VI-VIII, and X were isolated as by-products and identified by means of spectra.Compounds Ia and Ib were transformed in five steps to the title componds XVab and XVIab which were found inactive in tests for central depressant and anticonvulsant activity.