N,N-Bis(trimethylsilyl)methoxymethylamine as a Convenient Synthetic Equivalent for +CH2NH2: Primary Aminomethylation of Esters

DOI: 10.1039/c39840000883

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 883 - 884 (1984)

Update date:2022-08-05

Topics: Experimental Esters Synthetic equivalent

Authors:

Okano, Kohji

Morimoto, Toshiaki

Sekiya, Minoru

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Article abstract of DOI:10.1039/c39840000883

The introduction of a primary aminomethyl unit at the α position of esters can be achieved in high yield by the silyl trifluoromethanesulphonate-catalysed reaction of ketene silyl acetals (2) with N,N-bis(trimethylsilyl)methoxymethylamine (1).

Full text of DOI:10.1039/c39840000883

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Product name:Benzeneacetic acid, a-[[bis(trimethylsilyl)amino]methyl]-, methyl ester

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