94189-82-9

Upstream product

• 146952-74-1 5'-O-triethylsilylthymidine 
• 94219-34-8 Dithiophosphoric acid O-{(2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl} ester S,S'-diphenyl ester 
• 80585-43-9 Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester 
• 50-89-5 thymidine 
• 102573-69-3 5'-O-(4-4'-dimethoxytrityl)-N³-benzoyl thymidine 
• 94189-75-0 N³-benzoyl thymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 94189-81-8 3,3'-O,N-dibenzoylthymidine 
• 94189-77-2 triethylammonium S-phenyl 5'-O-(4,4'-dimethoxytrityl)-3-N-benzoylthymidine 3'-phosphorothioate 
• 112475-42-0 tris(2,4,6-tribromo-phenoxy)dichlorophosphorane 

Downstream Products

• 35002-96-1 thymidine 3'-[thymidine 5'-(ethyl phosphate)] 
• 121349-15-3 C₄₃H₄₉N₄O₁₄P 
• 87007-52-1 C₄₂H₄₇N₄O₁₄P 
• 144290-83-5 C₆₄H₆₁N₄O₁₇P 
• 102538-11-4 methyl 5'-O-dimethoxytrityl-N³-benzoylthymidin-3'-yl N³,3'-O-dibenzoylthymidin-5'-yl phosphate 

Relevant academic research and scientific papers

TRIS(2,4,6-TRIBROMOPHENOXY)DICHLOROPHOSPHORANE: A NOVEL CONDENSING AGENT FOR RAPID INTERNUCLEOTID BOND FORMATION IN THE PHOSPHOTRIESTER APPROACH

A new class of condensing agent, Tris(2,4,6-tribromophenoxy)-dichlorophosphorane (BDCP), was applied to the oligodeoxyribonucleotide synthesis.This reagent enabled us to perform a rapid internucleotidic bond formation in the phosphotriester approach only

BIS(2,4,6-TRIHALOPHENOXY)TRICHLOROPHOSPHORANES: NOVEL CONDENSING REAGENTS FOR INTERNUCLEOTIDIC PHOSPHOTRIESTER BOND FORMATION VIA ACTIVE PHOSPHOROCHLORIDATE INTERMEDIATES

New types of reagents, bis(2,4,6-trihalophenoxy)trichlorophosphoranes, were very effective as condensing agents for internucleotidic bond formation in the phosphotriester method.The 31P NMR study showed that the condensation proceeded via phosphorochloridate intermediates.

A NEW CLASS OF CONDENSING REAGENTS FOR RAPID INTERNUCLEOTIDE BOND FORMATION IN THE PHOSPHOTRIESTER APPROACH AND PREPARATION OF N3-BENZOYLTHYMIDINE AS A KEY INTERMEDIATE IN OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS

Rapid internucleotide bond formation in the phosphotriester approach has been achieved in high yield by use of bis(2,4,6-trihalophenyl)phosphorochloridates (TCP and TBP) as new condensing reagents and the benzoyl group as the N3-imide protecting group of thymidine.