87007-52-1Relevant academic research and scientific papers
Rapid and efficient syntheses of phosphorylated dinucleotides
Ferris,Peyser
, p. 1087 - 1111 (2007/10/02)
Nine or ten-step solution phase syntheses of the dimers dpApA, dApAp, dpTpT and dTpTp in 0.1-0.5 g amounts, in overall yields of 49%, 45%, 32%, and 20% respectively, are described. The synthetic intermediates were characterized by 1H and 3
Transformation of Dinucleoside S-Aryl Phosphorothioates into the Corresponding O-Alkyl Phosphates by Use of Tributyltin Alkoxides
Ohuchi, Shokichi,Ayukawa, Hiroshi,Hata, Tsujiaki
, p. 1501 - 1504 (2007/10/02)
Several alkyl dinucleoside phosphotriesters were easily obtained by use of the reaction of S-aryl dinucleoside phosphorothioates with tributyltin alkoxides.This reaction proceeds at room temperature under neutral conditions.
A Building Block for the Sequence-Specific Introduction of Cis-Syn Thymine Dimers into Oligonucleotides. Solid-Phase Synthesis of TpTpTpT
Taylor, John-Stephen,Brockie, Ian R.,O'Day, Christine L.
, p. 6735 - 6742 (2007/10/02)
We report the synthesis of a synthetic intermediate for the sequemce specific incorporation of the cis-syn thymine dimer into oligonucleotides via phosphoramidite-based solid-phase DNA synthesis technology.The required phosphoramidite 1a was obtained in f
Improvements in Oligodeoxyribonucleotide Synthesis: Methyl N,N-Dialkylphosphoramidite Dimer Units for Solid Support Phosphite Methodology
Kumar, G.,Poonian, M.S.
, p. 4905 - 4912 (2007/10/02)
Two procedures for the synthesis of methyl N,N-dialkylphosphoramidite dinucleotides (dimer units) compatible with the current solid support phosphite methodology of oligodeoxynucleotide synthesis are described for the first time.In the first procedure a c
