943034-50-2

Usage

Uses

Used in Pharmaceutical Research:
5-(2-chloroethyl)-2,3-dihydrobenzofuran is used as a chemical intermediate for the synthesis of pharmaceutical compounds due to its potential reactivity and the presence of the 2-chloroethyl group, which can be involved in substitution or alkylation reactions.
Used in Anticancer Drug Development:
In the field of oncology, 5-(2-chloroethyl)-2,3-dihydrobenzofuran is considered for its potential as an anticancer agent. Benzofuran derivatives have shown promise in this area, and further research is required to determine the specific contribution of the 2-chloroethyl group to its anticancer properties.
Used in Neurodegenerative Disease Treatment Research:
5-(2-chloroethyl)-2,3-dihydrobenzofuran is also being explored for its potential role in the treatment of neurodegenerative diseases. The benzofuran class of compounds has shown some activity in this field, and the unique structure of this derivative may offer additional benefits.
Used in Chemical Synthesis Industry:
In the chemical synthesis industry, 5-(2-chloroethyl)-2,3-dihydrobenzofuran is used as a building block for the creation of more complex organic molecules, leveraging its reactivity for substitution or alkylation processes to form a variety of new compounds.

InChI:InChI=1/C10H11ClO/c11-5-3-8-1-2-10-9(7-8)4-6-12-10/h1-2,7H,3-6H2

Upstream product

• 87776-76-9 5-(2-hydroxyethyl)-2,3-dihydrobenzofuran 
• 64089-34-5 2-chloro-1-(2,3-dihydrobenzofuran-5-yl)ethanone 

Downstream Products

• 133099-07-7 (S)-darifenacin hydrobromide 
• 133099-04-4 darifenacin 
• 586346-94-3 darifenacin hydrochloride 
• 1072227-73-6 2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester 
• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 

Relevant academic research and scientific papers

PREPARATION OF DARIFENACIN AND ITS SALTS

Provided are various processes and compounds related to darifenacin and/or its salts. For example, there is provided a process for preparing a free base of darifenacin: Formula, or the salt thereof, the process including reacting 3-(S)-(cyanodiphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl) ethyl] pyrrolidine of the Formula (IV), or a salt thereof: Formula (IV) with a base effective to convert the nitrile group of the compound of the Formula (IV) to the amide group of the darifenacin in an organic solvent, the reaction being carried out in the organic solvent, with a proviso that the solvent is not 2-methyl-butan-2-ol, and with further proviso that the reaction produces less than about 0.5 % of the compound of the Formula (Ic): Formula (Ic) in the reaction mass, as measured by HPLC. Various embodiments and variants are provided.

NOVEL AND IMPROVED PROCESSES FOR THE PREPARATION OF INTERMEDIATES OF DARIFENACIN, DARIFENACIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

The present invention relates to novel and improved processes for the preparation of intermediates of darifenacin, darifenacin and its pharmaceutically acceptable salts. Darifenacin is chemically known as 3 -(S)-(-)-(l -carbamoyl- 1,1 -diphenylmethyl)-l- [2- (2,3-dihydro benzofuran-5-yl)ethyl]pyrrolidine and represented by formula-2. The invention also relates to the novel polymorphs of the pharmaceutically acceptable salts of darifenacin and the methods for their re aration.

PROCESSES FOR PREPARING DARIFENACIN HYDROBROMIDE

The invention encompasses processes for the preparation of darifenacin hydrobromide.