64089-34-5

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloroacetyl-2,3-dihydrobenzofuran is used as a potential drug candidate for its potential biological activity. It may contribute to the development of new drugs due to its unique structure and properties.
Used in Organic Synthesis:
5-Chloroacetyl-2,3-dihydrobenzofuran serves as a building block in organic synthesis, facilitating the creation of various complex organic molecules and compounds.
Used in Fine Chemicals Production:
In the production of fine chemicals, 5-Chloroacetyl-2,3-dihydrobenzofuran is utilized for its unique structural attributes, contributing to the synthesis of specialty chemicals required across multiple industries.
Due to its distinctive features, 5-Chloroacetyl-2,3-dihydrobenzofuran garners interest from researchers and chemists, who explore its applications and potential in advancing scientific and industrial endeavors.

InChI:InChI=1/C10H9ClO2/c11-6-9(12)7-1-2-10-8(5-7)3-4-13-10/h1-2,5H,3-4,6H2

Upstream product

• 496-16-2 2.3-dihydrobenzofuran 
• 541-88-8 Chloroacetic anhydride 
• 271-89-6 1-benzofurane 
• 625-36-5 2-chloropropionyl chloride 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 943034-50-2 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride 
• 133034-08-9 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride 
• 133034-07-8 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine 
• 917815-10-2 C₃₁H₃₀FNO₆S 
• 133099-07-7 (S)-darifenacin hydrobromide 
• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 
• 1072227-73-6 2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester 
• 586346-94-3 darifenacin hydrochloride 
• 133099-04-4 darifenacin 
• 1187524-55-5 C₃₅H₃₇FN₄O₈S 
• 917815-16-8 C₃₈H₄₀FN₃O₈S 
• 1187524-29-3 C₄₄H₅₃FN₄O₁₀S 

Relevant academic research and scientific papers

PREPARATION OF DARIFENACIN AND ITS SALTS

Provided are various processes and compounds related to darifenacin and/or its salts. For example, there is provided a process for preparing a free base of darifenacin: Formula, or the salt thereof, the process including reacting 3-(S)-(cyanodiphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl) ethyl] pyrrolidine of the Formula (IV), or a salt thereof: Formula (IV) with a base effective to convert the nitrile group of the compound of the Formula (IV) to the amide group of the darifenacin in an organic solvent, the reaction being carried out in the organic solvent, with a proviso that the solvent is not 2-methyl-butan-2-ol, and with further proviso that the reaction produces less than about 0.5 % of the compound of the Formula (Ic): Formula (Ic) in the reaction mass, as measured by HPLC. Various embodiments and variants are provided.

SUBSTITUTED AZABICYCLO HEXANE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS

This invention relates to derivatives of substituted azabicyclo hexanes.The compound of this invention can function as muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors.The invention also relates to a process for the preparation of compounds of the present invention, pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

Acylation of aromatic ethers over solid acid catalysts: Scope of the reaction with more complex acylating agents

Acylation of anisole with 2-phenylbutanoic acid derivatives, over zeolite catalysts, gives the corresponding 4-acyl derivatives with high regioselectivity. In an analogous way, 2,3-dihydrobenzofuran reacts with acid anhydrides or chlorides in the presence

PYRROLIDINE DERIVATIVES

Compounds of the formula STR1 wherein R, Y and R 1 are as defined in the specification. These compounds are muscarinic receptor antagonists which are selective for smooth muscle muscarinic sites over cardiac muscarinic sites, and are useful in the treatment of diseases associated with altered motility on tone of smooth muscle, including irritable bowel syndrome, diverticular disease, urinary incontinence, oesophageal achalasia and chronic obstructive airways disease.