64089-34-5

Basic information

• Product Name: 5-Chloroacetyl-2,3-dihydrobenzofuran
• Synonyms: Ethanone, 2-chloro-1-(2,3-dihydro-5-benzofuranyl)-
• CAS NO: 64089-34-5
• Molecular Formula: C₁₀H₉ClO₂
• Molecular Weight: 196.64
• Mol File: 64089-34-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 354.1°C at 760 mmHg
• Flash Point: 161.5°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 3.44E-05mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 5-Chloroacetyl-2,3-dihydrobenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloroacetyl-2,3-dihydrobenzofuran(64089-34-5)
• EPA Substance Registry System: 5-Chloroacetyl-2,3-dihydrobenzofuran(64089-34-5)

Safety Data

• Hazardous Substances Data: 64089-34-5(Hazardous Substances Data)

Usage

General Description

5-Chloroacetyl-2,3-dihydrobenzofuran is a chemical compound that belongs to the benzofuran class of molecules. It is characterized by the presence of a chloroacetyl group and a dihydrobenzofuran ring structure. 5-Chloroacetyl-2,3-dihydrobenzofuran has potential applications in the field of pharmaceuticals, as it may exhibit biological activity and has the potential to be used in the development of new drugs. Additionally, it may also be used as a building block in organic synthesis, and in the production of various fine chemicals. Due to its unique structure and properties, 5-Chloroacetyl-2,3-dihydrobenzofuran is of interest to researchers and chemists in several different industries.

InChI:InChI=1/C10H9ClO2/c11-6-9(12)7-1-2-10-8(5-7)3-4-13-10/h1-2,5H,3-4,6H2

Upstream product

• 271-89-6 1-benzofurane 
• 625-36-5 2-chloropropionyl chloride 
• 496-16-2 2.3-dihydrobenzofuran 
• 79-04-9 chloroacetyl chloride 
• 541-88-8 Chloroacetic anhydride 

Downstream Products

• 943034-50-2 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride 
• 133034-08-9 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine hydrochloride 
• 133034-07-8 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)-2-oxoethyl]-pyrrolidine 
• 1187524-29-3 C₄₄H₅₃FN₄O₁₀S 
• 917815-16-8 C₃₈H₄₀FN₃O₈S 
• 1187524-55-5 C₃₅H₃₇FN₄O₈S 
• 133099-04-4 darifenacin 
• 586346-94-3 darifenacin hydrochloride 
• 1072227-73-6 2,2-diphenyl-2-{(S)-1-[2-(2,3-dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-acetic acid methyl ester 
• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 
• 133099-07-7 (S)-darifenacin hydrobromide 
• 917815-10-2 C₃₁H₃₀FNO₆S 

Relevant articles and documents

PREPARATION OF DARIFENACIN AND ITS SALTS

Provided are various processes and compounds related to darifenacin and/or its salts. For example, there is provided a process for preparing a free base of darifenacin: Formula, or the salt thereof, the process including reacting 3-(S)-(cyanodiphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl) ethyl] pyrrolidine of the Formula (IV), or a salt thereof: Formula (IV) with a base effective to convert the nitrile group of the compound of the Formula (IV) to the amide group of the darifenacin in an organic solvent, the reaction being carried out in the organic solvent, with a proviso that the solvent is not 2-methyl-butan-2-ol, and with further proviso that the reaction produces less than about 0.5 % of the compound of the Formula (Ic): Formula (Ic) in the reaction mass, as measured by HPLC. Various embodiments and variants are provided.

Acylation of aromatic ethers over solid acid catalysts: Scope of the reaction with more complex acylating agents

Acylation of anisole with 2-phenylbutanoic acid derivatives, over zeolite catalysts, gives the corresponding 4-acyl derivatives with high regioselectivity. In an analogous way, 2,3-dihydrobenzofuran reacts with acid anhydrides or chlorides in the presence