943442-82-8 Usage
General Description
The chemical "1,2-Ethanedione, 1-(5-fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-" is a complex compound with a structure that includes 1,2-ethanedione, and a combination of various pyridine rings and triazolo rings. The compound contains a fluorine atom and a methyl group on the 2-pyridinyl ring. The presence of these groups and rings suggests potential biological activity, as pyridine and triazolo compounds are often associated with pharmacological applications. Further research and analysis would be needed to fully understand the properties and potential uses of this chemical.
Check Digit Verification of cas no
The CAS Registry Mumber 943442-82-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,3,4,4 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 943442-82:
(8*9)+(7*4)+(6*3)+(5*4)+(4*4)+(3*2)+(2*8)+(1*2)=178
178 % 10 = 8
So 943442-82-8 is a valid CAS Registry Number.
InChI:InChI=1S/C14H9FN4O2/c1-8-10(15)3-4-11(18-8)14(21)13(20)9-2-5-12-16-7-17-19(12)6-9/h2-7H,1H3
943442-82-8Relevant articles and documents
Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-β type i receptor kinase
Krishnaiah, Maddeboina,Jin, Cheng Hua,Sheen, Yhun Yhong,Kim, Dae-Kee
, p. 5228 - 5231 (2015/11/09)
To further optimize a clinical candidate 5 (EW-7197), a series of 5-(3-, 4-, or 5-fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles 19a-l have been synthesized and evaluated for their TGF-β type I receptor kinase (ALK5) and p38α MAP kinase inhibitory activity in an enzyme assay. The 5-(5-fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles 19h-l displayed the similar level of potency to that of 5 against both ALK5 (IC50 = 7.68-13.70 nM) and p38α MAP kinase (IC50 = 1240-3370 nM). Among them, 19j inhibited ALK5 with IC50 value of 7.68 nM in a kinase assay and displayed 82% inhibition at 100 nM in a luciferase reporter assay.
