943442-82-8 Usage
Uses
Given the provided materials, there are no explicit uses mentioned for 1,2-Ethanedione, 1-(5-fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-yl-. However, based on the structural features of the compound, one can hypothesize potential applications in various fields:
Used in Pharmaceutical Industry:
1,2-Ethanedione, 1-(5-fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-ylcould be used as a lead compound for drug development due to its complex structure and the presence of pharmacologically relevant groups. The pyridine and triazolo rings are common in medicinal chemistry, and the fluorine and methyl substitutions may confer specific biological activities or improve pharmacokinetic properties.
Used in Chemical Research:
As a complex organic molecule, 1,2-Ethanedione, 1-(5-fluoro-6-Methyl-2-pyridinyl)-2-[1,2,4]triazolo[1,5-a]pyridin-6-ylmight serve as a subject of study in chemical research to explore its reactivity, stability, and potential to form new compounds through further synthetic modifications.
Check Digit Verification of cas no
The CAS Registry Mumber 943442-82-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,3,4,4 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 943442-82:
(8*9)+(7*4)+(6*3)+(5*4)+(4*4)+(3*2)+(2*8)+(1*2)=178
178 % 10 = 8
So 943442-82-8 is a valid CAS Registry Number.
InChI:InChI=1S/C14H9FN4O2/c1-8-10(15)3-4-11(18-8)14(21)13(20)9-2-5-12-16-7-17-19(12)6-9/h2-7H,1H3
943442-82-8Relevant articles and documents
Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-β type i receptor kinase
Krishnaiah, Maddeboina,Jin, Cheng Hua,Sheen, Yhun Yhong,Kim, Dae-Kee
, p. 5228 - 5231 (2015/11/09)
To further optimize a clinical candidate 5 (EW-7197), a series of 5-(3-, 4-, or 5-fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles 19a-l have been synthesized and evaluated for their TGF-β type I receptor kinase (ALK5) and p38α MAP kinase inhibitory activity in an enzyme assay. The 5-(5-fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles 19h-l displayed the similar level of potency to that of 5 against both ALK5 (IC50 = 7.68-13.70 nM) and p38α MAP kinase (IC50 = 1240-3370 nM). Among them, 19j inhibited ALK5 with IC50 value of 7.68 nM in a kinase assay and displayed 82% inhibition at 100 nM in a luciferase reporter assay.
2-Aminoimidazoles inhibitors of TGF-β receptor 1
Bonafoux, Dominique,Chuaqui, Claudio,Boriack-Sjodin, P. Ann,Fitch, Chris,Hankins, Gretchen,Josiah, Serene,Black, Cheryl,Hetu, Gregg,Ling, Leona,Lee, Wen-Cherng
scheme or table, p. 912 - 916 (2009/10/15)
The 4-(5-fluoro-6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-ylamine 3 is a potent and selective inhibitor of TGF-βR1. Substitution of the amino group of 3 typically led to a slight decrease in the affinity for the receptor and in TGF-β-inducted
