94361-26-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-chlorophenyl)-2-(1-cyclopropylethyl)oxirane is used as an anticonvulsant medication for the treatment of epilepsy. It modulates the activity of the neurotransmitter GABA in the brain, leading to a reduction in the frequency and severity of seizures.
Used in Epilepsy Treatment:
2-(4-chlorophenyl)-2-(1-cyclopropylethyl)oxirane is used as an adjunctive therapy in combination with other antiepileptic drugs for controlling seizures in patients with Dravet syndrome, a severe form of epilepsy.
Available in Oral Suspension and Tablet Forms:
2-(4-chlorophenyl)-2-(1-cyclopropylethyl)oxirane is available for use under medical supervision in oral suspension and tablet forms to ensure proper dosage and administration.

Upstream product

• 10524-06-8 (±)-(1-chloroethyl)cyclopropane 
• 104-88-1 4-chlorobenzaldehyde 
• 937-20-2 p-chlorophenacyl chloride 
• 36982-56-6 (2-bromoethyl)cyclopropane 
• 74-95-3 1,1-dibromomethane 
• 123989-29-7 1-(p-chlorophenyl)-2-cyclopropyl-2-methylethan-1-one 
• 75-18-3 dimethylsulfide 

Downstream Products

• 1258158-18-7 2-(4-chloro-phenyl)-3-cyclopropyl-1-(5-mercapto-[1,2,4]triazol-1-yl)-butan-2-ol 
• 94361-06-5 cyproconazol 

Relevant academic research and scientific papers

Novel preparation method of cycloazole alcohol

The invention relates to the field of organic synthesis, in particular to a novel preparation method of cycloazole alcohol. The method includes following steps: (1), allowing 2, 4'-dichloroacetophenone to be in nucleophilic addition reaction with 1-cyclopropyl halogenated ethane Grignard reagent or 1-cyclopropyl halogenated ethane organic zinc reagent to generate 1-chloro-2-(4-chlorphenyl)-3-cyclopropyl butyl-2-alcohol or 2-(4-chlorphenyl)-2-(1-cyclopropy ethyl)-ethylene oxide or a mixture of the two; (2), enabling the product of the step (1) to be in nucleophilic substitution reaction with 1,2, 4-triazole or 1, 2, 4-triazole salt to obtain cycloazole alcohol; or enabling 1-chloro-2-(4-chlorphenyl)-3-cyclopropyl butyl-2-alcohol to react with alkali to generate 2-(4-chlorphenyl)-2-(1-cyclopropy ethyl)-ethylene oxide, then being in ring-opening reaction with 1, 2, 4-triazole or 1, 2, 4-triazole salt to obtain cycloazole alcohol. The preparation method is short in path, high in yield, needless of sulfur reagent with foul odor, highly toxic reagent and noble metal catalyst expensive in price in the process of reaction and suitable for large-scale industrial production.

Through 1 - chloro -2 - (4 - chlorophenyl) -3 - methyl -4 - pentene -2 - alcohol preparation triabimefron method

The invention relates to the field of organic synthesis, in particular to a through 1 - chloro - 2 - (4 - chlorophenyl) - 3 - methyl - 4 - pentene - 2 - ol preparation triabimefron method, comprises the following steps: (1) 2, 4' - dichloro ethanone deprotecting reagent or organic zinc reagent nucleophilic addition reaction, generating 1 - chloro - 2 - (4 - chlorophenyl) - 3 - methyl - 4 - pentene - 2 - ol, 2 - (4 - chlorophenyl) - 2 - (d - 3 - en - 2 - yl) - ethylene oxide or a mixture of both; (2) step (1) the product obtained with the halogeno methane ring 1 - chloro - 2 - (4 - chlorophenyl) - 3 - cyclopropyl-d - 2 - ol, 2 - (4 - chlorophenyl) - 2 - (1 - cyclopropyl-ethyl) - ethylene oxide or a mixture of both; (3) step (2) product with 1, 2, 4 - triazole or 1, 2, 4 - three nitrogen zuozuo salt undergo nucleophilic substitution reaction to obtain triabimefron. The invention provides a method for preparing triabimefron short route, high yield, the reaction process does not use a foul smell of sulfur reagent, not with the use of toxic reagent, also without the use of a noble metal catalyst, suitable for large-scale industrial production.

Preparation method of cyproconazole

The invention relates to a preparation method of cyproconazole as shown in the chemical structural formula I. According to the preparation method, 4-chlorobenzaldehyde is selected as a raw material to undergo a Grignard reaction to obtain a key intermediate 1-(4-chlorophenyl)-2-cyclopropyl-1-propanol; and 1-(4-chlorophenyl)-2-cyclopropyl-1-propanol undergoes an oxidation reaction, and then Sulfur ylide reaction and ring-opening reaction are successively carried out to prepare cyproconazole. Preparation reaction is as shown in the specification, wherein an oxidizing agent is selected from N-halosuccinimide, 1,3-dihalo-5,5-dimethyl hydantoin or ketone-alkoxy-aluminium; a sulfur ylide reagent is prepared by carrying out a reaction between (CH3)2S and (CH3)2SO4 under the action of KOH in isobutanol; DBU is 1,8-diazabicyalo[5.4.0]C11-7-en; and NMP is N-methylpyrrolidine.

ANTIFUNGAL 1,2,4-TRIAZOLYL DERIVATIVES HAVING A 5- SULFUR SUBSTITUENT

The present invention relates to novel triazole compounds of the formulae (I) and (Il) as defined below, to agricultural and pharmaceutical compositions containing them and to their use as fungicides antiviral and anticancer agents.