123989-29-7Relevant academic research and scientific papers
Synthesis method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone
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Paragraph 0050; 0069; 0074-0077, (2021/07/17)
The invention provides a synthesis method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. The method is shown in the following reaction process. The method comprises the following steps: 1) performing addition elimination on a p-chlorobenzyl halide metal reagent and cyclopropyl methyl ketone to obtain a compound as shown in a formula (II); and 2) oxidizing the compound as shown in the formula (II) to obtain a compound as shown in a formula (I), namely 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. The method provided by the invention has the advantages of short synthetic route, high yield, low raw material cost, green and environment-friendly process, suitability for industrial large-scale production and the like.
Synthesis method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone
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Paragraph 0027; 0030-0031; 0034, (2020/02/10)
The invention relates to a synthesis method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone, which comprises the following steps: 1) carrying out condensation on alpha-halogen substituted p-chlorobenzylphosphonate and cyclopropylmethyl ketone under alkaline conditions to obtain an alkenyl halide compound; and 2) hydrolyzing the alkenyl halide compound prepared in the step 1) to obtain the 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. According to the synthetic method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone, alpha-halogen substituted p-chlorobenzyl phosphonate and cyclopropylmethyl ketone are condensed under the alkaline condition to obtain the alkenyl halide compound, the obtained alkenyl halide compound is hydrolyzed to obtain 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone, the whole technological process is simple and smooth, reaction conditions are mild, and the method is suitable for industrial large-scale production; alpha-halogen substituted p-chlorobenzyl phosphonate and cyclopropylmethyl ketone are used as reaction substrates, so that the method is high in atom economy, green, environment-friendly and low in raw material cost.
One-pot synthesis of α,α-disubstituted Aryl-1-ethanones via the Wittig-Horner reaction
Yang, Yunxia,Wang, Le,Chen, Yuan,Dai, Yiru,Sun, Zhihua
, p. 121 - 126 (2018/01/04)
A one-pot methodology for the synthesis of α,α-disubstituted aryl-1-ethanones via the Wittig-Horner reaction has been developed and described in this manuscript. Both aryl/alkyl and dialkyl α-branched arylethanone were obtained in high yields (up to 96%) without the use of any metal catalysts. A total of 14 α,α-disubstituted arylethanone derivatives were synthesized based on this simple method that easily converts the carbonyl carbon (sp2) into the sp3 carbon. This versatile method is expected to further promote the use of substituted ketones as synthetic building blocks to construct a variety of α-branched aryl ketones.
Preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-actone
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Paragraph 0029; 0061-0062, (2018/04/03)
The invention provides a preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-actone. The 1-(4-chlorphenyl)-2-cyclopropyl-1-actone is prepared by reacting a compound of a structure in Formula (II)with p-chlorobenzaldehyde. The reaction raw material is low in price and easy to obtain, and the production cost is greatly reduced; the synthetic route is short and simple in technique; the raw material preparation and synthesis of the 1-(4-chlorphenyl)-2-cyclopropyl-1-actone are free from waste water, thus the risk to people and environment is reduced; and the green and environment-friendly chemical industry development requirement is met.
A 1 - (4 - chlorophenyl) -2 - cyclopropyl -1 - acetone synthetic method
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Paragraph 0016; 0017, (2018/10/02)
The invention discloses a 1 - (4 - chlorophenyl) - 2 - cyclopropyl - 1 - propanone synthetic method, in formula (I) of the formula (II) compound as a raw material, in the presence of a catalyst prepared by cross-coupling reaction of 1 - (4 - chlorophenyl) - 2 - cyclopropyl - 1 - propanone. The invention selective (I) of the formula (II) compound as the raw material for preparing 1 - (4 - chlorophenyl) - 2 - cyclopropyl - 1 - propanone, compared with the prior art, the reaction of the invention raw materials are easy, short synthetic route, the process is simple, after treatment is simple, the production cost is low, and the obtained 1 - (4 - chlorophenyl) - 2 - cyclopropyl - 1 - propanone high purity, in 98.5% or more, the yield and the reaction conversion is also high, the product yield is 80 - 92%.
C-H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow
Dingwall, Paul,Greb, Andreas,Crespin, Lorène N.S.,Labes, Ricardo,Musio, Biagia,Poh, Jian-Siang,Pasau, Patrick,Blakemore, David C.,Ley, Steven V.
supporting information, p. 11685 - 11688 (2018/11/02)
The difficulty in accessing and safely utilising non-stabilised diazo species has in the past limited the application of this class of compounds. Here we explore further the use of oxadiazolines, non-stabilised diazo precursors which are bench stable, in direct, non-catalytic, aldehyde C-H functionalisation reactions under UV photolysis in flow and free from additives. Commercially available aldehydes are coupled to afford unsymmetrical aryl-alkyl and alkyl-alkyl ketones while mild conditions and lack of transition metal catalysts allow for exceptional functional group tolerance. Examples are given on small scale and in a larger scale continuous production.
Preparation method of cyproconazole intermediate 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone
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Paragraph 0014, (2018/10/19)
The invention discloses a preparation method of cyproconazole intermediate1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. Compounds in a formula (I) and a formula (II) are taken as raw materials and are subjected to a weinreb ketone synthesis reaction, and 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone is prepared. The compounds in the formula (I) and the formula (II) are taken as raw materials for preparation of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. Compared with the prior art, the preparation method has the advantages that reaction raw materials are easy to obtain, no catalyst is used, the synthesis route is short, the process is simple and the production cost is low; 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone has high purity reaching 98.5% or above, higher yield being 80%-88% and higher conversion rate.
A 1 - (4 - chlorophenyl) - 2 - cyclopropyl - 1 - propanone preparation method
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, (2017/08/26)
The invention relates to a 1-(4-chlorophenyl)-2-cyclopropyl-1-propanone preparation method. The preparation method comprises that chlorobenzyl alcohol, sodium nitrite, acetic acid and concentrated hydrochloric acid undergo a reaction, the reaction product is treated to form a compound I, the compound I and cyclopropyl methyl ketone undergo a condensation reaction in the presence of an alkali and a solvent, the reaction product is treated to form a compound II, the compound II undergoes a reduction reaction in the presence of a reducer and a solvent, the reaction product is treated to form a compound III, the compound III undergoes a reduction reaction in the presence of a reducer and a solvent, and the reaction product is treated to form 1-(4-chlorophenyl)-2-cyclopropyl-1-propanone. The preparation method has the advantages of simple processes, use of cheap and easily available raw materials, low cost, less three wastes, industrial production feasibility and high product yield and content.
Preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone
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, (2017/11/04)
The invention discloses a preparation method of 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. The method comprises the steps of preparing acetal by adopting p-chlorobenzaldehyde and phenylcarbinol or a derivative thereof as raw materials under the action of a catalyst, reacting an acetal product with trimethyl phosphite or triethyl phosphite in an environment of a polar solvent under the catalysis of lewis acid to generate alpha-benzyloxy p-chlorobenzyl dimethyl phosphate, further reacting the alpha-benzyloxy p-chlorobenzyl dimethyl phosphate with cyclopropyl methyl ketone under the combined action of a base catalyst, a phase transfer catalyst and a cocatalyst to prepare a benzyloxy-propylene derivative; and then carrying out acidifying hydrolysis on the benzyloxy-propylene derivative to obtain the1-(4-chlorphenyl)-2-cyclopropyl-1-acetone. Compared with the prior art, the method has the advantages of being safe in operation, controllable in process, low in toxicity in the process, mild in reaction condition, suitable for industrial production and high in product purity.
A 1 - (4 - chlorophenyl) - 2 - cyclopropyl - 1 - propanone synthetic method
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Paragraph 0038; 0039; 0040; 0041; 0042; 0043; 0044-0049, (2017/08/25)
The invention relates to a synthetic method of 1-(4-chlorophenyl)-2-cyclopropyl-1-propanone. The synthetic method comprises steps as follows: (1), hydroxy lamine hydrochloride is dissolved in a solvent, alkali is added, the pH (potential of hydrogen) value is adjusted, a raw material of cyclopropyl propionaldehyde is added at the appropriate temperature for a reaction, and cyclopropyl acetaldoxime is obtained through extraction, concentration and drying after the reaction ends; (2), newly prepared p-chlorophenyl diazonium salt and a catalyst are added to cyclopropyl acetaldoxime at the lower temperature, acid is added, the mixture is heated to have a reaction, and 1-(4-chlorophenyl)-2-cyclopropyl-1-propanone is obtained through aftertreatment after the reaction ends. The synthetic route is shown in the specification. The synthetic method has the advantages as follows: the cost of raw materials is low, the overall yield of the reaction is high, the technological operation is safe, aftertreatment is simple and convenient, and the synthetic method has industrial application value.
