94379-05-2

Usage

Uses

Used in Pharmaceutical Industry:
(R,S)-N-benzylpiperidine-3-carboxamide is used as a potential treatment for neurological and psychiatric disorders due to its ability to modulate dopamine and serotonin levels in the brain. It is being studied for its potential as an antidepressant and antipsychotic medication.
Used in Neurological Disorders Treatment:
(R,S)-N-benzylpiperidine-3-carboxamide is used as a potential treatment for Parkinson's disease, as it may help in modulating the neurotransmitter levels affected by this condition.
Used in Psychiatric Disorders Treatment:
(R,S)-N-benzylpiperidine-3-carboxamide is used as a potential treatment for depression, given its effects on modulating neurotransmitter levels that are often imbalanced in individuals with this disorder.
Used in Addiction and Substance Abuse Treatment:
(R,S)-N-benzylpiperidine-3-carboxamide is used as a potential treatment for addiction and substance abuse, as it has been investigated for its potential to help individuals recover from these conditions.
However, it is important to note that further research is needed to fully understand the therapeutic potential and safety profile of (R,S)-N-benzylpiperidine-3-carboxamide.

Upstream product

• 71962-74-8 Ethyl nipecotate 
• 952-92-1 1-Benzyl-1,4-dihydronicotinamide 
• 4138-26-5 nipecotamide 
• 100-52-7 benzaldehyde 
• 100-39-0 benzyl bromide 
• 72551-53-2 ethyl 1-benzylpiperidine-3-carboxylate 
• 67-56-1 methanol 

Downstream Products

• 168466-80-6 (R)-N-benzylpiperidine-3-carboxamide 
• 1222710-49-7 (S)-N-benzylpiperidine-3-carboxylic acid 
• 1222710-49-7 C₁₃H₁₇NO₂ 
• 91820-96-1 1-benzyl-piperidine-3-carbonitrile 

Relevant academic research and scientific papers

Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes

The search for affordable, green biocatalytic processes is a challenge for chemicals manufacture. Redox biotransformations are potentially attractive, but they rely on unstable and expensive nicotinamide coenzymes that have prevented their widespread expl

SUBSTITUTED 3- AND 4- AMINOMETHYLPIPERIDINES FOR USE AS BETA-SECRETASE IN THE TREATMENT OF ALZHEIMER’S DISEASE

The invention relates to novel compounds, which are substituted chiral or achiral derivatives of 3- or 4- aminomethylpiperidine of the general formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of general formula (I) and especially their use as inhibitors of beta-secretases for the treatment of Alzheimer’s disease.

A convenient route to 1-benzyl 3-aminopyrrolidine and 3-aminopiperidine

1-Benzyl 3-aminopyrrolidine 1 and 1-benzyl 3-aminopiperidine 2 were prepared rapidly mainly in aqueous conditions in 55 and 75% yields, respectively, on a multi-gram scale starting from inexpensive and commercially available starting materials. The key step involved the Curtius rearrangement mediated by sodium nitrite and trifluoroacetic acid of the appropriate acylhydrazides. All the reactions (except LAH reductions) were performed in water.