944937-03-5

Basic information

• Product Name: C₁₆H₁₈N₂O₂
• Synonyms: C₁₆H₁₈N₂O₂
• CAS NO: 944937-03-5
• Molecular Weight: 270.331
• Mol File: 944937-03-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₈N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₈N₂O₂(944937-03-5)
• EPA Substance Registry System: C₁₆H₁₈N₂O₂(944937-03-5)

Safety Data

• Hazardous Substances Data: 944937-03-5(Hazardous Substances Data)

Upstream product

• 17694-68-7 3-(2-bromoacetyl)pyridine hydrobromide 
• 104-63-2 N-Benzylethanolamine 
• 350-03-8 methyl-3-pyridylketone 
• 6221-12-1 3-Bromoacetylpyridine 

Downstream Products

• 944937-04-6 C₁₆H₂₀N₂O₂ 
• 944937-05-7 4-benzyl-2-pyridin-3-yl-morpholine 
• 90437-05-1 2-Pyridyl-(3)-morpholin 

Relevant articles and documents

Muscarinic receptor 1 agonist activity of novel N-aryl carboxamide substituted 3-morpholino arecoline derivatives in Alzheimer's presenile dementia models

Earlier we have reported the effect of arecoline thiazolidinone and morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimer's presenile dementia models. To elucidate further our Structure-Activity Relationship (SAR) studies on the chemistry and muscarinic receptor 1 binding efficacy, a series of novel carboxamide derivatives of 2-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine molecule have been designed and synthesized as a new class of M1 receptor agonists with a low toxicity effect profile that enhances memory function in animal models of Alzheimer's presenile dementia and also modulates the APP secretion from rat brain cerebrocortical slices by activating M1 receptor in vitro. Results suggest that compound 9b having methyl group at the para position of the aryl group attached to the carboxamide of morpholino arecoline could emerge as a potent molecule having antidementia activity.