133706-01-1

Upstream product

• 51146-39-5 trimethylsilyl ester of aci-nitrophenylmethane 
• 94594-91-9 acrylcamphorsultam 
• 622-42-4 1-nitro-1-phenylmethane 
• 119897-85-7 N-<(4,5-dihydro-3-methyl-(5R)-5-isoxazolyl)carbonyl>-(2R)-bornane-10,2-sultam 
• 119897-86-8 N-<(4,5-dihydro-3-ethyl-(5R)-5-isoxazolyl)carbonyl>-(2R)-bornane-10,2-sultam 
• 94594-90-8 (2R)-bornane-10,2-sultam 
• 100-39-0 benzyl bromide 
• 51146-39-5 trimethylsilyl phenylmethane nitronate 

Downstream Products

• 119897-84-6 ((3aS,6R,7aR)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)((R)-3-phenyl-4,5-dihydroisoxazol-5-yl)methanone 
• 119897-84-6 ((3aS,6R,7aR)-8,8-dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)((S)-3-phenyl-4,5-dihydroisoxazol-5-yl)methanone 

Relevant academic research and scientific papers

Asymmetric induction in silyl nitronate cycloadditions to Oppolzer's chiral sultam derivatives

Silyl nitronate cycloadditions to Oppolzer's chiral sultam derivatives, followed by the elimination of the silyl alcohols from the resulting N-silyloxyisoxazolidines, provide Δ2-isoxazolines in good stereoselectivity (ca. 89/11). The favored transition state is suggested in the light of the X-ray crystal structure of a major cycloadduct.

Asymmetric silyl nitronate cycloadditions with bornane-10,2-sultam derivatives

Asymmetric silyl nitronate cycloadditions with N-acryloyl (2R)-bornane-10,2-sultam, N-acryloyl (2S)-bornane-10,2-sultam, and N-methacryloyl (2R)-bornane-10,2-sultam have been studied. The asymmetric silyl nitronate cycloaddition/elimination methodology pr