94615-58-4Relevant academic research and scientific papers
Straightforward microwave-assisted synthesis of 2-thiazolines using Lawesson's reagent under solvent-free conditions
Seijas, Julio A.,Vázquez-Tato, M. Pilar,Crecente-Campo, José
, p. 9280 - 9285 (2008/12/21)
2-Thiazolines are synthesized from carboxylic acids and 1,2-aminoalcohols in the presence of Lawesson's reagent under solventless conditions. The developed method is valid for either substituted or unsubstituted aminoalcohols and a wide variety of aromatic, heteroaromatic and aliphatic carboxylic acids; thus it constitutes a general synthetic method for these kinds of compounds. The role of Lawesson's reagent is dual: to transform the 1,2-aminoalcohol into 1,2-aminothiol and to activate its reaction with the carboxylic acid leading to the formation of a thiazoline ring, all in one pot.
NICKEL-CATALYZED REACTIONS OF THIAZOLES, ISOXAZOLES, OXAZOLINES AND THIAZOLINES WITH GRIGNARD REAGENTS
Wenkert, Ernest,Han, Aili
, p. 929 - 937 (2007/10/02)
Grignard reagents convert thiazoles, isoxazoles, oxazolines and thiazolines into N-vinylimines, β-amino-α,β-unsaturated ketones, tetrahydrooxazoles and tetrahydrothiazoles, respectively, under the influence of phosphine-ligated nickel species.The reaction characteristics and the uncatalyzed reactions are described.
Studies on β-Lactams: Synthesis of Some Penams, Cephams and Their 1-Oxa Analogs
Sharma, S. D.,Mehra, Usha,Kaur, Sukhjinder
, p. 857 - 859 (2007/10/02)
5,6-Dihydro-4-hydroxy-4-methyl-2-phenyl-1,3-thiazine (1a), after the protection of its hydroxy group with trimethylsilyl chloride, reacts with phenoxyacetyl chloride in the presence of triethylamine to give the hydroxycepham (IIa). 1,3-Oxazines (Ib and Ic
