94615-59-5

Upstream product

• 124-68-5 2-Amino-2-methyl-1-propanol 
• 100-09-4 4-methoxybenzoic acid 
• 100-07-2 4-methoxy-benzoyl chloride 
• 94615-60-8 N-(1,1-dimethyl-2-hydroxyethyl)-p-methoxybenzamide 

Downstream Products

• 94615-62-0 (5S,6R)-5-(4-Methoxy-phenyl)-2,2-dimethyl-6-phenoxy-4-thia-1-aza-bicyclo[3.2.0]heptan-7-one 

Relevant academic research and scientific papers

Straightforward microwave-assisted synthesis of 2-thiazolines using Lawesson's reagent under solvent-free conditions

2-Thiazolines are synthesized from carboxylic acids and 1,2-aminoalcohols in the presence of Lawesson's reagent under solventless conditions. The developed method is valid for either substituted or unsubstituted aminoalcohols and a wide variety of aromatic, heteroaromatic and aliphatic carboxylic acids; thus it constitutes a general synthetic method for these kinds of compounds. The role of Lawesson's reagent is dual: to transform the 1,2-aminoalcohol into 1,2-aminothiol and to activate its reaction with the carboxylic acid leading to the formation of a thiazoline ring, all in one pot.

Studies on β-Lactams: Synthesis of Some Penams, Cephams and Their 1-Oxa Analogs

5,6-Dihydro-4-hydroxy-4-methyl-2-phenyl-1,3-thiazine (1a), after the protection of its hydroxy group with trimethylsilyl chloride, reacts with phenoxyacetyl chloride in the presence of triethylamine to give the hydroxycepham (IIa). 1,3-Oxazines (Ib and Ic