94615-60-8

Basic information

• Product Name: Benzamide, N-(2-hydroxy-1,1-dimethylethyl)-4-methoxy-
• CAS NO: 94615-60-8
• Molecular Formula: C12H17NO3
• Molecular Weight: 223.272
• Mol File: 94615-60-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(2-hydroxy-1,1-dimethylethyl)-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(2-hydroxy-1,1-dimethylethyl)-4-methoxy-(94615-60-8)
• EPA Substance Registry System: Benzamide, N-(2-hydroxy-1,1-dimethylethyl)-4-methoxy-(94615-60-8)

Safety Data

• Hazardous Substances Data: 94615-60-8(Hazardous Substances Data)

Upstream product

• 100-07-2 4-methoxy-benzoyl chloride 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 100-09-4 4-methoxybenzoic acid 

Downstream Products

• 94615-62-0 (5S,6R)-5-(4-Methoxy-phenyl)-2,2-dimethyl-6-phenoxy-4-thia-1-aza-bicyclo[3.2.0]heptan-7-one 
• 94615-63-1 (5S,6S)-5-(4-Methoxy-phenyl)-2,2-dimethyl-6-phenoxy-4-oxa-1-aza-bicyclo[3.2.0]heptan-7-one 
• 94615-59-5 2-(4-Methoxy-phenyl)-4,4-dimethyl-4,5-dihydro-thiazole 
• 53416-46-9 2-(4-methoxyphenyl)-4,4-dimethyl-2-oxazoline 

Relevant articles and documents

Preparation of Polyfunctionalized Aromatic Nitriles from Aryl Oxazolines

A selective ortho,ortho’-functionalization of readily available aryl oxazolines by two successive magnesiations with sBu2Mg in toluene followed by trapping reactions with electrophiles, such as (hetero)aryl iodides or bromides, iodine, tosyl cyanide, ethyl cyanoformate or allylic bromides (39 examples, 62–99 % yield) is reported. Treatment of these aryl oxazolines with excess oxalyl chloride and catalytic amounts of DMF (50 °C, 4 h) provided the corresponding nitriles (36 examples, 73–99 % yield). Conversions of these nitriles to valuable heterocycles are reported, and a tentative mechanism is proposed.

Spiro compounds

Spiro compounds of the general formula (I): wherein Ar1represents an optionally substituted aryl or heteroaryl; n represents 0 or 1; T, U, V and W each represent a nitrogen atom or an optionally substituted methine group, wherein at least two of which represent said methine group; X represents methine; Y represents an optionally substituted imino or oxygen atom. These novel spiro compounds exhibit neuropeptide Y receptor (NPY) antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders, central nervous system disorders, metobolic diseases and the like.

Studies on β-Lactams: Synthesis of Some Penams, Cephams and Their 1-Oxa Analogs

5,6-Dihydro-4-hydroxy-4-methyl-2-phenyl-1,3-thiazine (1a), after the protection of its hydroxy group with trimethylsilyl chloride, reacts with phenoxyacetyl chloride in the presence of triethylamine to give the hydroxycepham (IIa). 1,3-Oxazines (Ib and Ic