94662-50-7

Basic information

• Product Name: N-[2-[[5-(dimethylaminomethyl)-2-furyl]methylsulfanyl]ethyl]-8,8-dioxo -3,8$l^{6}-dithiabicyclo[3.3.0]octa-1,4,6-trien-6-amine
• Synonyms: N-[2-[[5-(dimethylaminomethyl)-2-furyl]methylsulfanyl]ethyl]-8,8-dioxo -3,8$l^{6}-dithiabicyclo[3.3.0]octa-1,4,6-trien-6-amine
• CAS NO: 94662-50-7
• Molecular Formula: C16H20N2O3S3
• Molecular Weight: 384.5366
• Mol File: 94662-50-7.mol

Chemical Properties

• Boiling Point: 565.6°Cat760mmHg
• Flash Point: 295.9°C
• Appearance: /
• Density: 1.4g/cm³
• Vapor Pressure: 8.2E-13mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: N-[2-[[5-(dimethylaminomethyl)-2-furyl]methylsulfanyl]ethyl]-8,8-dioxo -3,8$l^{6}-dithiabicyclo[3.3.0]octa-1,4,6-trien-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-[[5-(dimethylaminomethyl)-2-furyl]methylsulfanyl]ethyl]-8,8-dioxo -3,8$l^{6}-dithiabicyclo[3.3.0]octa-1,4,6-trien-6-amine(94662-50-7)
• EPA Substance Registry System: N-[2-[[5-(dimethylaminomethyl)-2-furyl]methylsulfanyl]ethyl]-8,8-dioxo -3,8$l^{6}-dithiabicyclo[3.3.0]octa-1,4,6-trien-6-amine(94662-50-7)

Safety Data

• Hazardous Substances Data: 94662-50-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H20N2O3S3/c1-18(2)7-12-3-4-13(21-12)8-22-6-5-17-15-11-24(19,20)16-10-23-9-14(15)16/h3-4,9-11,17H,5-8H2,1-2H3

Upstream product

• 66356-53-4 5-{[(2-aminoethyl)thio]methyl}-N,N-dimethyl-2-furfurylamine 
• 94662-49-4 3-(methylthio)thieno<3,4-d>isothiazole 1,1-dioxide 
• 15433-79-1 (5-dimethylaminomethyl-furan-2-yl)-methanol 
• 59337-79-0 thieno(3,4-d)-1,2-thiazol-3(2H)-one 1,1-dioxide 
• 51-80-9 bis-(dimethylamino)methane 
• 123703-36-6 N-<2-<(2-furanylmethyl)thio>ethyl>thieno<3,4-d>isothiazol-3-amine 1,1-dioxide 
• 94662-48-3 thieno[3,4-d]isothiazole-3(2H)-thione 1,1-dioxide 

Relevant articles and documents

A potent gastric acid anti-secretory histamine H2 receptor antagonist, N--2-furanyl>methyl>thio>ethyl>thienoisothiazol-3-amine 1,1-dioxide, hydrochloride (Wy-45,727)

The synthesis of the title compound, a new histamine H2-receptor antagonist (pA2=8.2), (Wy-45,727;7) is described.Its gastric acid anti-secretory potencies in the rat and dog were found to be significantly greater than those of cimetidine or ranitidine. anti-secretory / H2-receptor antagonist / N--2-furanyl>methyl>thio>ethyl>thieno-isothiazol-3-amine 1,1-dioxide hydrochloride / Wy-45,727

Process for preparing thieno-fused heterocyclic anti-ulcer agents and intermediates therefor

A process for preparing certain thieno-fused heterocyclic compounds having H2 -receptor antagonist and antisecretory activity, which involves the reaction of a mercaptan, obtained by reduction of a thienoisothiazole amino alkyl disulfide, with a 5-substituted-2-furanylmethanol; and said thienoisothiazole amino alkyl disulfide intermediates.

Process for preparing thieno-fused heterocyclic anti-ulcer agents

A process for preparing certain thieno-fused heterocyclic compounds having H2 -receptor antagonist and antisecretory activity, which comprises reacting a suitable thienoisothiazole derivative with an appropriate (furanylmethylthio)ethanamine derivative to yield an intermediate, which is subjected to cyclization to yield the desired final product.