A potent gastric acid anti-secretory histamine H2 receptor antagonist, N--2-furanyl>methyl>thio>ethyl>thienoisothiazol-3-amine 1,1-dioxide, hydrochloride (Wy-45,727)

DOI: 10.1016/0223-5234(89)90169-4

Source and publish data:

European Journal of Medicinal Chemistry p. 87 - 90 (1989)

Update date:2022-08-24

Topics:

Authors:

Santilli, Arthur A.

Scotese, Anthony C.

Morris, Robert L.

Nielsen, Susan T.

Strike, Donald P.

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Article abstract of DOI:10.1016/0223-5234(89)90169-4

The synthesis of the title compound, a new histamine H2-receptor antagonist (pA₂=8.2), (Wy-45,727;7) is described.Its gastric acid anti-secretory potencies in the rat and dog were found to be significantly greater than those of cimetidine or ranitidine. anti-secretory / H2-receptor antagonist / N-<2-<<<5-<(dimethylamino)methyl>-2-furanyl>methyl>thio>ethyl>thieno<3,4-d>-isothiazol-3-amine 1,1-dioxide hydrochloride / Wy-45,727

Full text of DOI:10.1016/0223-5234(89)90169-4

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