99355-57-4Relevant academic research and scientific papers
Catalyst-free Mannich-type reaction of 1-(N-acylamino)alkyltriphenylphosphonium salts with silyl enolates
Pa?dzierniok-Holewa, Agnieszka,Wal?cka-Kurczyk, Alicja,Musio?, Szymon,Stecko, Sebastian
, p. 732 - 742 (2019/01/10)
A catalyst-free reaction of 1-(N-acylamino)alkyltriphenylphosphonium tetrafluoroborates with silyl enolates was developed to prepare β-amino carbonyl compounds. The reported method is a useful approach for the preparation of N-protected β-amino esters as
N-amides, Versatile Amidoalkylation Reagents. 5. A General and Convenient Route to N-(α-Alkoxyalkyl)amides
Katritzky, Alan R.,Fan, Wei-Qiang,Black, Michael,Pernak, Juliusz
, p. 547 - 549 (2007/10/02)
N-amides 2, easily prepared from benzotriazole 1, an aldehyde, and an amide, react readily with a variety of primary and secondary alcohols under mild conditions to give N-(α-alkoxyalkyl)amides 3 in good yield.
Synthesis of N-(α-Methoxyalkyl) Amides from Imidates
Lokensgard, Jerrold P.,Fischer, John W.,Bartz, William J.
, p. 5609 - 5611 (2007/10/02)
Two general routes from imidates to N-(α-methoxyalkyl) amides (e.g.,R'CONHCH(OCH3)R, 1) are reported.The first involves acylation of the imidate on nitrogen with an acyl chloride, followed by reduction with sodium borohydride.In the second, an aldehyde is converted, via its methyl acetal, to an α-chloro methyl ether, which is used to alkylate the imdate.Further treatment with pyridinium chloride in dry Me2SO yields 1.Thirteen examples are reported.
