94726-00-8Relevant articles and documents
PYRROLO-PYRROLE CARBAMATE AND RELATED ORGANIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF
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Paragraph 00550; 00551, (2015/01/16)
The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, Ν,Ν-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.
Asymmetric organozincate additions to ethyl 2,2,2-trifluoropyruvate
Gosselin, Francis,Britton, Robert A.,Mowat, Jeffrey,O'Shea, Paul D.,Davies, Ian W.
, p. 2193 - 2196 (2008/02/10)
A chromatography-free synthesis of enantiomerically enriched chiral α-trifluoromethyl α-hydroxy acids prepared via an asymmetric (R)-BINOL-mediated organozincate addition to ethyl 2,2,2-trifluoropyruvate (1) is reported. Georg Thieme Verlag Stuttgart.
An efficient protocol for the reduction of ketones with tin(II) complexes and PMHS
Lawrence, Nicholas J.,Bushell, Simon M.
, p. 4507 - 4512 (2007/10/03)
A mixture of tin(II) triflate/pybox and polymethylhydrosiloxane (PMHS) in methanol effects the efficient reduction of ketones; the use of an enantiomerically pure pybox ligand leads to moderate enantioselectivity. (C) 2000 Elsevier Science Ltd.
