94739-24-9

Upstream product

• 141-97-9 ethyl acetoacetate 
• 6334-18-5 2,3-dichlorobenzylaldehyde 

Downstream Products

• 108932-05-4 4-(2,3-dichlorophenyl)-1,4-dihydro-2-[[(4-methoxyphenyl)methyl]thio]-6-methyl-5-pyrimidinecarboxylic acid, ethyl ester 
• 108931-48-2 1,4-dihydro-2-methoxy-6-methyl-4-(2,3-dichlorophenyl)-5-pyrimidinecarboxylic acid, ethyl ester 
• 106720-55-2 4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-2-(methylthio)-5-pyrimidinecarboxylic acid ethyl ester 
• 72509-76-3 ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate 
• 112080-30-5 Ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 112080-24-7 Ethyl 4-(2,3-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 175688-78-5 4-(2,3-Dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-ethyl ester 
• 96382-71-7 Dehydrofelodipine 

Relevant academic research and scientific papers

A new process for the preparation of felodipine (by machine translation)

The invention discloses a new process for the preparation of felodipine, including: 1) to acetyl acetic acid methyl ester as the raw material, to prepare the 3 - amino-crotonic acid methyl ester; 2) to 2, 3 - dichloro formaldehyde and acetyl acetic acid ethyl ester as the raw material, to prepare the 2, 3 - two chlorine asia phenmethyl acetyl ethyl acetate; 3) to 2, 3 - two chlorine asia phenmethyl acetyl ethyl acetate, 3 - amino-crotonic acid methyl ester as the raw material, prepare the felodipine. The invention of the preparation process of felodipine, intermediates for the preparation of 3 - amino-crotonic acid methyl ester having a melting point of 83 - 35 °C, far higher than the widely used of the intermediate 3 - amino-crotonic acid ethyl ester (33 - 35 °C), therefore the stability can be improved, convenient in a wider temperature conditions production and storage, is more favorable to the industrialized production and application. At the same time, the process high product yield, high purity, step is simple, easy to operate, and has good practicability. (by machine translation)

Design, synthesis and spectroscopic and crystallographic characterisation of novel functionalized pyrazole derivatives: biological evaluation for their cytotoxic, angiogenic and antioxidant activities

Abstract: The current study presents the synthesis of functionalized pyrazoles (18–29) through 3 + 2 annulation reaction of ethyl 2-(arylidene)-3-oxobutanoates (8–13) with phenylhydrazine hydrochlorides (14–17) in acetic acid under reflux conditions. Stru

Catalytic effect of nanosized metal oxides on the knoevenagel reaction

The effect of nanosized metal oxides (Al, Mg, Cu, Ni oxides) on the synthesis of chalcones that are key intermediate in the synthesis of Nitrendipine and Felodipine drugs was examined.

Combinatorial Synthesis of Functionalized 1,3-Thiazine Libraries Using a Combined Polymer-Supported Reagent/Catch-and-Release Strategy

A dual role: The supported sulfonic acid reagent promotes the ring closure of the thiazine products and also binds them in situ as ion pairs (see scheme). The nonbasic by-products and excess reagents can be removed by filtration and the products subsequen