947748-55-2

Upstream product

• 773147-11-8 (2,2,5,7,8-pentamethylchroman-6-sulfonyl)isothiocyanate 
• 90-04-0 2-methoxy-phenylamine 
• 161117-67-5 2,2,5,7,8-pentamethylchroman-6-sulfonamide 
• 112160-39-1 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride 

Downstream Products

• 947748-66-5 N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-allyl-N''-(o-methoxyphenyl)guanidine 
• 947748-67-6 C₅₇H₆₆N₆O₈S₂ 

Relevant academic research and scientific papers

Strategies for the solid-phase diversification of poly-L-proline-type II peptide mimic scaffolds and peptide scaffolds through guanidinylation

(Chemical Equation Presented) A strategy for the solid-phase diversification of PPII mimic scaffolds through guanidinylation is presented. The approach involves the synthesis N-Pmc-N′-alkyl thioureas as diversification reagents. Analogues of Fmoc-Orn(Mtt)-OH can be incorporated into a growing peptide chain on Wang resin. Side chain deprotection with 1% TFA/CH2Cl2 followed by EDCI-mediated reaction of N-Pmc-N′-alkyl thioureas with the side chain amine affords arginine analogues with modified guanidine head groups. The scope, limitations, and incidental chemistry are discussed.

Synthetic routes to N-Pmc-N′,N″-disubstituted guanidines via EDCI-mediated guanylation of amines with N-Pmc-N′-substituted thioureas

An overview of the facile and high-yielding EDCI-mediated reaction of amines with N-Pmc-N′-alkyl thioureas to afford guanidines is presented, in which the general scope and limitations of the reaction are probed. It was found that the N-sulfonyl-N′-substi