94871-76-8Relevant academic research and scientific papers
Recyclable keggin heteropolyacids as an environmentally benign catalyst for the synthesis of new 2-benzoylamino-n-phenyl-benzamide derivatives under microwave irradiations at solvent-free conditions and the evaluation of biological activity
Ighilahriz-Boubchir, Karima,Boutemeur-Kheddis, Baya,Rabia, Cherifa,Makhloufi-Chebli, Malika,Hamdi, Maamar,Silva, Artur M. S.
, (2018/01/03)
2-Benzoylamino-N-phenyl-benzamide derivatives (5a–h) were prepared from 2-phenyl-3,1-(4H)-benzoxazin-4-one 3 and substituted anilines 4a–h in the presence of a Keggin-type heteropolyacids series (H3PW12O40·13H2O
Synthesis of 3-substituted and 2,3-disubstituted quinazolinones via Cu-catalyzed aryl amidation
Xu, Lanting,Jiang, Yongwen,Ma, Dawei
supporting information; experimental part, p. 1150 - 1153 (2012/03/27)
CuI/4-hydroxy-l-proline catalyzed coupling of N-substituted o-bromobenzamides with formamide takes place at 80 °C, affording 3-substituted quinazolinones directly. Under these conditions other amides that were tested only provided simple coupling products, which can be converted into 2,3-disubstituted quinazolinones via HMDS/ZnCl2 mediated condensative cyclization.
Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: Search for anticancer agent
Noolvi, Malleshappa N.,Patel, Harun M.,Bhardwaj, Varun,Chauhan, Ankit
experimental part, p. 2327 - 2346 (2011/06/25)
The synthesis of some 2-furano-4(3H)-quinazolinones, diamides (open ring quinazolines), quinoxalines and their biological evaluation as antitumor agents using National Cancer Institute (NCI) disease oriented antitumor screen protocol are investigated. Among the synthesize compounds, seventeen compounds were granted NSC code and screened at National Cancer Institute (NCI), USA for anticancer activity at a single high dose (10-5 M) in full NCI 60 cell panel. Among the selected compounds, 3-(2-chloro benzylideneamine)-2- (furan-2-yl) quinazoline-4(3h)-one 21 was found to be the most active candidate of the series at five dose level screening against Ovarian OVCAR-4 and Non-small cell lung cancer NCI-H522 with GI50 1.82 & 2.14 μM respectively. Rational approach and QSAR techniques enabled the understanding of the pharmacophoric requirement for quinazoline, diamides and quinoxaline derivatives.
Hexamethyldisilazane-iodine induced intramolecular dehydrative cyclization of diamides: a general access to natural and unnatural quinazolinones
Kshirsagar, Umesh A.,Mhaske, Santosh B.,Argade, Narshinha P.
, p. 3243 - 3246 (2008/02/02)
A simple and efficient general approach to various quinazolinone scaffolds, including peptidomimetic examples, has been demonstrated by employing HMDS/I2 for the intramolecular dehydrative cyclization of diamides. The protecting groups -Boc, -F
Synthesis and anti-inflammatory activity of 2,3-diaryl-4(3H)-quinazolinones
Yadav,Shirude,Parmar,Balaraman,Giridhar
, p. 1038 - 1045 (2008/09/16)
2,3-Diaryl-4(3H)-quinazolinones containing various substituents on diaryl rings have been synthesized and evaluated for their cyclooxygenase-2 inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay and anti-inflammatory activity by the carrageenan-induced rat paw edema assay. 2-(4-Nitrophenyl)-3-(4-tolyl)-4(3H)-quinazolinone showed a maximum COX-2 inhibition of 27.72% at 22 μM concentration in the present series and exhibited a mild anti-inflammatory activity at a dose of 50 mg/kg in carrageenan-induced rat paw edema assay.
