94871-76-8

Basic information

• Product Name: 2-(benzoylamino)-N-(4-methylphenyl)benzamide
• Synonyms: 2-(benzoylamino)-N-(4-methylphenyl)benzamide
• CAS NO: 94871-76-8
• Molecular Formula: C₂₁H₁₈N₂O₂
• Molecular Weight: 330.37982
• Mol File: 94871-76-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(benzoylamino)-N-(4-methylphenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzoylamino)-N-(4-methylphenyl)benzamide(94871-76-8)
• EPA Substance Registry System: 2-(benzoylamino)-N-(4-methylphenyl)benzamide(94871-76-8)

Safety Data

• Hazardous Substances Data: 94871-76-8(Hazardous Substances Data)

Upstream product

• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 106-49-0 p-toluidine 
• 579-93-1 2-(Benzoylamino)benzoic Acid 
• 136926-09-5 2-bromo-N-(4-methylphenyl)benzamide 
• 55-21-0 benzamide 
• 118-92-3 anthranilic acid 
• 98-88-4 benzoyl chloride 
• 32212-38-7 2-amino-N-(4-methylphenyl)benzamide 

Downstream Products

• 37856-14-7 2-phenyl-3-(4-tolyl)quinazolin-4(3H)-one 
• 1310341-21-9 2-benzamido-N-(4-(4-phenylbuta-1,3-dienyl)phenyl)benzamide 

Relevant articles and documents

Recyclable keggin heteropolyacids as an environmentally benign catalyst for the synthesis of new 2-benzoylamino-n-phenyl-benzamide derivatives under microwave irradiations at solvent-free conditions and the evaluation of biological activity

2-Benzoylamino-N-phenyl-benzamide derivatives (5a–h) were prepared from 2-phenyl-3,1-(4H)-benzoxazin-4-one 3 and substituted anilines 4a–h in the presence of a Keggin-type heteropolyacids series (H3PW12O40·13H2O

Synthesis and in vitro antitumor activity of substituted quinazoline and quinoxaline derivatives: Search for anticancer agent

The synthesis of some 2-furano-4(3H)-quinazolinones, diamides (open ring quinazolines), quinoxalines and their biological evaluation as antitumor agents using National Cancer Institute (NCI) disease oriented antitumor screen protocol are investigated. Among the synthesize compounds, seventeen compounds were granted NSC code and screened at National Cancer Institute (NCI), USA for anticancer activity at a single high dose (10-5 M) in full NCI 60 cell panel. Among the selected compounds, 3-(2-chloro benzylideneamine)-2- (furan-2-yl) quinazoline-4(3h)-one 21 was found to be the most active candidate of the series at five dose level screening against Ovarian OVCAR-4 and Non-small cell lung cancer NCI-H522 with GI50 1.82 & 2.14 μM respectively. Rational approach and QSAR techniques enabled the understanding of the pharmacophoric requirement for quinazoline, diamides and quinoxaline derivatives.

Synthesis and anti-inflammatory activity of 2,3-diaryl-4(3H)-quinazolinones

2,3-Diaryl-4(3H)-quinazolinones containing various substituents on diaryl rings have been synthesized and evaluated for their cyclooxygenase-2 inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay and anti-inflammatory activity by the carrageenan-induced rat paw edema assay. 2-(4-Nitrophenyl)-3-(4-tolyl)-4(3H)-quinazolinone showed a maximum COX-2 inhibition of 27.72% at 22 μM concentration in the present series and exhibited a mild anti-inflammatory activity at a dose of 50 mg/kg in carrageenan-induced rat paw edema assay.