37856-14-7

Basic information

• Product Name: 4(3H)-Quinazolinone, 3-(4-methylphenyl)-2-phenyl-
• Synonyms: 2-phenyl-3-p-tolyl-3H-quinazolin-4-one;2-phenyl-3-p-tolylquinazolin-4(3H)-one;2-Phenyl-3-p-tolyl-3H-chinazolin-4-on;2-phenyl-3-(p-tolyl)-quinazoline-4(3H)-one;2-phenyl-3-(4-tolyl)quinazolin-4(3H)-one
• CAS NO: 37856-14-7
• Molecular Formula: C21H16N2O
• Molecular Weight: 312.371
• Mol File: 37856-14-7.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: 4(3H)-Quinazolinone, 3-(4-methylphenyl)-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4(3H)-Quinazolinone, 3-(4-methylphenyl)-2-phenyl-(37856-14-7)
• EPA Substance Registry System: 4(3H)-Quinazolinone, 3-(4-methylphenyl)-2-phenyl-(37856-14-7)

Safety Data

• Hazardous Substances Data: 37856-14-7(Hazardous Substances Data)

Upstream product

• 707-07-3 orthobenzoic acid trimethyl ester 
• 32212-38-7 2-amino-N-(4-methylphenyl)benzamide 
• 94871-76-8 2-benzoylamino-N-(4-methylphenyl)benzamide 
• 100-52-7 benzaldehyde 
• 932-90-1 Benzaldoxime 
• 2272-45-9 benzal-p-toluidine 
• 611-71-2 MANDELIC ACID 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 100-47-0 benzonitrile 
• 134-20-3 2-carbomethoxyaniline 
• 5344-90-1 2-Aminobenzyl alcohol 
• 106-49-0 p-toluidine 
• 119072-55-8 tert-butylisonitrile 
• 98-80-6 phenylboronic acid 

Downstream Products

• 49699-38-9 2-phenyl-3-p-tolyl-3H-quinazoline-4-thione 

Relevant articles and documents

Complementary Reactivity in Selective Radical Processes: Electrochemistry of Oxadiazolines to Quinazolinones

Electrochemistry has recently emerged as a sustainable approach for efficiently generating radical intermediates utilizing eco-friendly electric energy. An electrochemical process was developed to transform 1,2,4-oxadiazolines under mild conditions. The electrochemical N-O bond cleavage at a controlled oxidation potential led to the selective synthesis of quinazolinone derivatives that could not be obtained by photocatalytic radical processes, indicating complementary reactivities in radical processes. The electrochemical reaction pathways were fully revealed by density functional theory-based investigations.

Preparation of 4(3H)-quinazolinones from aryldiazonium salt, nitriles and 2-aminobenzoate via a cascade annulation

One-pot synthesis of 3-aryl-4(3H)-quinazolinones has been realized through a cascade annulation. Reaction of aryldiazonium salt with a nitrile provides in situ generation of a reactive nitrilium ion, which is attacked by the amino group of 2-aminobenzoate followed by cyclization to deliver the desired product. This strategy offers a convenient and easy access to a wide range of functionalized quinazolinone.

Palladium-Catalyzed Oxidative Three-Component Coupling of Anthranilamides with Isocyanides and Arylboronic Acids: Access to 2,3-Disubstituted Quinazolinones

A novel palladium-catalyzed oxidative three-component coupling of easily accessible N-substituted anthranilamides with isocyanides and arylboronic acids is achieved. This protocol offers an alternative approach toward 2,3-disubstituted quinazolinones with a wide substrate scope and good functional group tolerance.