948846-57-9Relevant academic research and scientific papers
Macrocyclic Spiro Pyrimidine Derivatives
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Page/Page column 79, (2009/09/28)
Macrocyclic spiro pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein.
Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships
Zhao, Chen,Sun, Minghua,Bennani, Youssef L.,Miller, Thomas R.,Witte, David G.,Esbenshade, Timothy A.,Wetter, Jill,Marsh, Kennan C.,Hancock, Arthur A.,Brioni, Jorge D.,Cowart, Marlon D.
experimental part, p. 4640 - 4649 (2010/03/01)
A new histamine H3 receptor (H3R) antagonist chemotype 1 was designed by combining key pharmacophoric elements from two different precursor structural series and then simplifying and optimizing the resulting combined structural featu
OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES
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, (2008/06/13)
Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making th
