949-00-8

Upstream product

• 14758-48-6 Hexakis-phenylmercapto-ethan 
• 59611-77-7 1-(chloro-phenyl-methylene)-piperidinium; chloride 
• 108-98-5 thiophenol 
• 5616-55-7 2-phenyl-1,3-dithiane 
• 4661-46-5 2-carboxybenzene diazonium chloride 
• 884-09-3 phenyl thiobenzoate 
• 82737-61-9 2,4-bis(methylthio)-1,3-dithia-2,4-diphosphetane-2,4-disulfide 
• 1483-72-3 diphenyliodonium chloride 
• 3682-36-8 dithiobenzoic acid sodium salt 
• 121-68-6 dithiobenzoic acid 
• 100-63-0 phenylhydrazine 
• 65-85-0 benzoic acid 
• 75-15-0 carbon disulfide 
• 13464-19-2 phenyl chlorothioformate 

Downstream Products

• 101611-90-9 2,3,5-triphenyl-2-phenylsulfanyl-2,3-dihydro-[1,3,4]thiadiazole 
• 87894-75-5 1-phenyl-3H-thiopyrano<3,4-b><1>benzothiophen-3-one 
• 629-45-8 dibutyl disulfide 
• 27249-89-4 Thiobenzoesaeure-n-butylthioester 
• 108-98-5 thiophenol 
• 882-33-7 diphenyldisulfane 
• 103-19-5 di(p-tolyl) disulfide 
• 884-09-3 phenyl thiobenzoate 
• 10371-42-3 S-(4-methylphenyl) thiobenzoate 
• 29627-34-7 4-(phenyldisulfanyl)toluene 
• 62740-57-2 benzyl(phenyl(phenylthio)methyl)sulfane 
• 2168-78-7 methyl dithiobenzoate 
• 100-68-5 methyl-phenyl-thioether 
• 501-65-5 diphenyl acetylene 

Relevant academic research and scientific papers

Compound embodiments that release H2S by reaction with a reactive compound and methods of making and using the same

Disclosed herein are embodiments of a donor compound that releases H2S by reacting with a reactive compound. The donor compound embodiments described herein can be used to deliver H2S to a subject or a sample and further can be used to administer therapeutic agents. The donor compound embodiments also can facilitate bioconjugation. Methods of making and using the donor compound embodiments also are disclosed.

Ynamide-Mediated Thionoester and Dithioester Syntheses

A novel ynamide-mediated synthesis of thionoesters and dithioesters is described. The selective addition reactions of various monothiocarboxylic acids with ynamide furnish α-thioacyloxyenamides, which undergo transesterification with nucleophilic -OH or -SH species to afford thionoesters and dithioesters, respectively. The broad substrate scope, mild reaction conditions, and excellent yields make this method an attractive synthetic approach to thionoesters and dithioesters.

The Dual Reactivity of 5-S/5-O-Phenyl-1,4,2-oxathiazoles: A Fragmentation Pathway That Affords Nitriles in the Presence of Water

The rearrangement of substituted 1,4,2-oxathiazoles to nitriles in the presence of water is described. Preliminary investigations suggest that the reaction pathway proceeds via a 1,4,2-oxathiazolium intermediate, followed by trapping with water and subsequent decomposition to products. An unprecedented rearrangement of 5-phenyl-1,4,2-oxathiazoles bearing a C5 leaving group to nitriles in the presence of water is described.

Investigations of the Thermal Responsiveness of 1,4,2-Oxathiazoles

The first systematic study of the thermal rearrangement/fragmentation of 5,5-disubstituted 1,4,2-oxathiazoles into isothiocyanates is reported. Structure-activity relationships reveal that the choice of substituent at the 5-position of the 1,4,2-oxathiazoles is the predominant factor to influence the ease of fragmentation.

Phosphorus pentasulfide: A mild and versatile catalyst/reagent for the preparation of dithiocarboxylic esters

(matrix presented) The reaction of carboxylic acids (1) with a variety of thiols or alcohols in the presence of phosphorus pentasulfide (P4S10) as a catalyst and reagent (20-40 mol %) proceeded effectively to afford the corresponding dithiocarboxylic esters (2) in high yields.

Kinetics and mechanism of the aminolysis of phenyl dithiobenzoates

The kinetics and mechanism of the reactions of phenyl dithiobenzoates with anilines in acetonitrile at 55.0 deg C have been studied.The large magnitude of βx(βnuc) and the signs of cross-interaction constants, ρeXY > 0, ρYZ XZ > 0, are all consistent with the carbonyl addition mechanism in which the breakdown of the tetrahedral intermediate, T+/-, is rate limiting.The thiocarbonyl group (C=S) is found to favour amine expulsion in contrast to the carbonyl group (C=O) which favours the S-bonded nucleofuge expulsion from T+/-.The signs of cross-interaction constants, ρXY, ρYZ and/or ρXZ, are shown to provide useful mechanistic criteria for distinguishing, especially, the carbonyl addition mechanism involving the rate-limiting breakdown of the tetrahedral intermediate (T+/- from the concerted SN2 mechanism.

Polyvalent Iodine in Synthesis; 3. An Efficient Method for the Synthesis of Aryl Arenedithiocarboxylates

A new method for the synthesis of aryl arenedithiocarboxylates consists of the S-arylation of sodium arenedithiocarboxylates with diaryliodonium chlorides or bromides in tert-butyl alcohol.

A New Rapid Synthesis of Phenyl Dithiocarboxylates

The otherwise difficultly accessible phenyl dithiocarboxylates are prepared in good yields by the reaction of S-phenyl carbonochloridothioate with halomagnesium or sodium dithiocarboxylates.